EPIUnit-Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
Unidade de Endocrinologia Pediátrica, Serviço de Pediatria, Centro Hospitalar Universitário de S. João, Porto, Portugal.
Clin Endocrinol (Oxf). 2022 Dec;97(6):747-754. doi: 10.1111/cen.14805. Epub 2022 Aug 9.
We aimed to explore the association between dehydroepiandrosterone sulphate (DHEAS) levels at age 7, pubertal development between ages 10 and 13, and age at menarche.
This is a longitudinal study of 603 individuals (301 girls, 302 boys) from the Generation XXI cohort.
Evaluation of the participants at ages 7, 10 and 13 included anthropometry and Tanner staging. Pubertal development between ages 10 and 13 was categorized using latent class analysis, based on Tanner stages. The association between DHEAS at age 7 and pubertal development between ages 10 and 13 was conducted with binomial logistic regression, adjusted for BMI z-score. The variation of age at menarche in relation to DHEAS levels at age 7, controlling for maternal age at menarche, birth weight z-score and BMI z-score, was estimated fitting a linear regression model.
Pubertal development at ages 10-13 was categorized into two classes-Class 1 had a higher probability for the lower Tanner stage (less advanced sexual maturation) and Class 2 had a higher probability for the higher Tanner stage (more advanced sexual maturation). In girls, taking Class 1 as a reference, Class 2 was positively associated with BMI z-score and DHEAS. In boys, Class 2 was positively associated with BMI, but not with DHEAS. DHEAS levels at age 7 were negatively associated with age at menarche, after adjustment for maternal age at menarche, birth weight and BMI.
In girls, but not in boys, DHEAS at age 7 was positively associated with more advanced pubertal development between ages 10 and 13, and with earlier age at menarche.
我们旨在探讨 7 岁时去氢表雄酮硫酸盐（DHEAS）水平、10-13 岁时青春期发育和初潮年龄之间的关系。
这是一项对 21 世纪队列中 603 名个体（301 名女孩，302 名男孩）的纵向研究。
对参与者在 7 岁、10 岁和 13 岁时进行了人体测量和 Tanner 分期评估。10-13 岁的青春期发育通过基于 Tanner 分期的潜在类别分析进行分类。采用二项逻辑回归分析 7 岁时 DHEAS 与 10-13 岁时青春期发育之间的关系，调整 BMI z 评分。在控制初潮年龄的母亲年龄、出生体重 z 评分和 BMI z 评分的情况下，使用线性回归模型估计 DHEAS 水平与初潮年龄之间的关系。
10-13 岁时的青春期发育分为两类——第 1 类更有可能处于较低的 Tanner 期（性成熟度较低），第 2 类更有可能处于较高的 Tanner 期（性成熟度较高）。在女孩中，以第 1 类为参考，第 2 类与 BMI z 评分和 DHEAS 呈正相关。在男孩中，第 2 类与 BMI 呈正相关，但与 DHEAS 无关。调整母亲初潮年龄、出生体重和 BMI 后，7 岁时的 DHEAS 水平与初潮年龄呈负相关。
在女孩中，而不是在男孩中，7 岁时的 DHEAS 与 10-13 岁时青春期发育更成熟和初潮年龄更早呈正相关。
