Manjila Sunil, Fana Michael, Medani Khalid, Kay Matthew D, Manjila Rehan, Bazil Timothy G, Udayasankar Unni
Neurosurgery, McLaren Bay Region Medical Center, Bay City, USA.
Neurology, Central Michigan University College of Medicine, Saginaw, USA.
Cureus. 2022 Jul 1;14(7):e26492. doi: 10.7759/cureus.26492. eCollection 2022 Jul.
Spinal epidural lipomatosis (SEL) is a rare condition characterized by an excessive accumulation of adipose tissue in the spinal canal that can have a compressive effect on intraspinal neuroanatomical structures, leading to clinical symptoms. Several different conservative and surgical treatment strategies have been proposed but the treatment and outcomes remain controversial. There is a lack of severity-based evidence documenting the success of decompressive laminectomy in SEL and there are only anecdotal reports of clinico-radiological success with weight loss from bariatric surgery. This article demonstrates the resolution of SEL in two patients with bariatric surgery with the help of pre and postoperative MR imaging. The authors also highlight the classic "types" of spinal epidural lipomatosis with a surgically relevant grading system and elucidate the existence of concurrent extraspinal lipomatosis (i.e. mediastinal and intra-abdominal lipomatosis), drawing parallels with the natural history of SEL. The controversial question remains whether a symptomatic SEL patient needs a multilevel laminectomy for spinal decompression or bariatric surgery that can indirectly help the spinal condition. We propose that bariatric intervention could be better frontline management in patients with multifocal/multisystem lipomatosis (i.e., combined spinal and extraspinal) and spinal decompression would be ideal for those SEL patients with coexisting bony and/or ligamentous spinal canal or foraminal stenosis. This manuscript serves as a comprehensive and contemporary update on the radiological profile and two plausible treatment paths and will look toward further verification by a randomized clinical trial.
脊髓硬膜外脂肪增多症(SEL)是一种罕见病症,其特征为椎管内脂肪组织过度积聚,可对椎管内神经解剖结构产生压迫作用,进而导致临床症状。目前已提出多种不同的保守和手术治疗策略,但治疗方法及效果仍存在争议。缺乏基于严重程度的证据证明减压性椎板切除术在SEL治疗中的成功,仅有关于减肥手术导致体重减轻从而取得临床影像学成功的轶事报道。本文借助术前和术后磁共振成像展示了两例接受减肥手术的患者SEL病情的缓解情况。作者还通过一个与手术相关的分级系统突出了脊髓硬膜外脂肪增多症的经典“类型”,阐明了并存的椎管外脂肪增多症(即纵隔和腹腔内脂肪增多症)的存在,并将其与SEL的自然病程进行了对比。有症状的SEL患者是需要进行多级椎板切除术以实现脊髓减压,还是需要进行减肥手术来间接改善脊髓状况,这一争议性问题依然存在。我们建议,对于多灶性/多系统脂肪增多症(即合并脊髓和椎管外脂肪增多症)患者,减肥干预可能是更好的一线治疗方法;而对于存在骨性和/或韧带性椎管或椎间孔狭窄的SEL患者,脊髓减压术则是理想的治疗方法。本文作为一篇关于放射学特征及两种可行治疗途径的全面且与时俱进的综述,期待通过随机临床试验进行进一步验证。