Lory P
Am J Physiol. 1987 Jun;252(6 Pt 2):F1095-102. doi: 10.1152/ajprenal.1987.252.6.F1095.
Based on morphological observations, it has been concluded that the upper parts of the long descending limbs of Henle's loops should be able to secrete salts into the tubular fluid (Kriz, W. Federation Proc. 42:2379-2385, 1983). In the same article, a hypothesis is given depicting how this active transport in concert with certain characteristics of the medullary architecture might produce a transport cascade toward the papillary tip, thus supporting the accumulation of salts in this region. The effectiveness of the proposed mechanism can be judged by a mathematical model only. The computer simulations of the present study demonstrate that this mechanism indeed leads to an increase of the concentrating capability of the renal countercurrent system.
基于形态学观察，已得出结论：亨氏袢长下行支的上部应能够向肾小管液中分泌盐分（克里兹，W. 《联邦会议论文集》42:2379 - 2385，1983年）。在同一篇文章中，给出了一个假说，描述了这种主动转运与髓质结构的某些特征协同作用，如何可能产生一个朝向乳头尖的转运级联反应，从而支持该区域盐分的积聚。所提出机制的有效性只能通过数学模型来判断。本研究的计算机模拟表明，该机制确实会导致肾逆流系统浓缩能力的增加。
