College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China.
School of Biological & Chemical Engineering, Zhejiang University of Science & Technology, Hangzhou, 310023, China.
Mol Nutr Food Res. 2022 Oct;66(19):e2200313. doi: 10.1002/mnfr.202200313. Epub 2022 Aug 9.
Wheat peptides (WP) are rich in glutamic acid, glutamine, and other bioactive compounds that may benefit gut function and health. This study aims to evaluate the effects of regular consumption of WP on constipation-induced complications and gut microbiota in humans and mice.
A randomized trial of 49 functional constipation participants is conducted. The weekly amount of spontaneous bowel movements (SBM) increases by 2.09 per week after WP treatment, and by 0.40 per week among the placebo group (PL). Concomitantly, the secondary outcomes show significant improvements in the quality of life-related to constipation (PAC-QOL), constipation severity, and satisfaction with the intervention. In the animal study, WP effectively alleviates constipation symptoms and affects the secretion of intestinal mobility-related neurotransmitters and gastrointestinal hormones in loperamide-induced constipation mice. Additionally, WP regulates the gene and protein expression levels of water-electrolyte metabolism and intestinal mobility. Furthermore, WP treatment decreases the abundance of several gut microbiota positively correlated to constipation (Turicibacter, Bacteroides_f_Bacteroidaceae, and Streptococcus) in mice.
WP ameliorates constipation in humans and mice, which could be partly explained by improving water-electrolyte metabolism, boosting intestinal motility, and reshaping gut microbiota.
小麦肽（WP）富含谷氨酸、谷氨酰胺和其他生物活性化合物，可能有益于肠道功能和健康。本研究旨在评估 WP 对人类和小鼠便秘相关并发症和肠道微生物群的影响。
对 49 名功能性便秘参与者进行了一项随机试验。WP 治疗后每周自发性排便次数（SBM）增加 2.09 次，而安慰剂组（PL）每周增加 0.40 次。同时，次要结局显示与便秘相关的生活质量（PAC-QOL）、便秘严重程度和对干预的满意度均有显著改善。在动物研究中，WP 有效缓解了便秘症状，并影响了洛哌丁胺诱导的便秘小鼠肠道运动相关神经递质和胃肠激素的分泌。此外，WP 调节了水-电解质代谢和肠道运动的基因和蛋白表达水平。此外，WP 治疗可减少与便秘呈正相关的几种肠道微生物群（Turicibacter、Bacteroides_f_Bacteroidaceae 和 Streptococcus）的丰度。
WP 可改善人类和小鼠的便秘，这在一定程度上可以通过改善水-电解质代谢、促进肠道动力和重塑肠道微生物群来解释。
