Department of Orthopedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Department of Pediatrics, Division of Pediatric Hematology and Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Clin Cancer Res. 2022 Oct 14;28(20):4360-4362. doi: 10.1158/1078-0432.CCR-22-1794.
The posterior HOXD enhancer is an EWSR1::FLI1-dependent regulator of HOXD13 expression in Ewing sarcoma. HOXD13 expression promotes a mesenchymal cell state. Through antagonistic transcriptional programs, EWSR1::FLI1 and HOXD13 serve as master regulators of Ewing cell plasticity. Targeting Ewing cells as they exist in/transition between mesenchymal states is a priority. See related article by Apfelbaum et al., p. 4466.
后部 HOXD 增强子是 Ewing 肉瘤中 EWSR1::FLI1 依赖性 HOXD13 表达的调节剂。HOXD13 的表达促进了间充质细胞状态。通过拮抗转录程序，EWSR1::FLI1 和 HOXD13 作为 Ewing 细胞可塑性的主要调节剂。以 Ewing 细胞存在于/过渡到间充质状态的状态为靶点是当务之急。见 Apfelbaum 等人的相关文章，第 4466 页。
