Faculty of Health Sciences, Department of Physical Therapy and Rehabilitation, Hasan Kalyoncu University, Gaziantep, Turkey.
Faculty of Medicine, Department of Pediatric Hematology-Oncology, Gaziantep University, Gaziantep, Turkey.
Haemophilia. 2022 Nov;28(6):e189-e198. doi: 10.1111/hae.14645. Epub 2022 Aug 3.
Knee joint proprioception is affected, and lower extremity functioning declines over time in patients with hemophilia A.
To investigate the effects of a structured exercise programme consisting of the close kinetic chain (CKC) exercises on proprioception and physical activity level in pediatric patients with hemophilia.
A total of 21 patients with hemophilia A who had at least one target knee joint were randomized into three groups: Study Group (SG, n = 7), Conventional Treatment Group (CTG, n = 7) and Control Group (CG, n = 7). The SG received a structured, lower limb-specific exercise protocol consisting of CKC exercises 2 days a week for 12 weeks, in addition to prophylactic treatment. The CTG received exercise training as described in the published literature. The CG continued to receive prophylactic treatment during the study period. Proprioception was measured using a digital goniometer before and after treatment in open and closed kinetic chain positions (CKCPs). The Five Times Sit to Stand (STS), Timed Up and Go (TUG) and Functional Independence Score in Hemophilia were used for the assessment of physical activity level.
A significant pre/post-treatment difference was found among the groups in proprioception (p = .001) and physical activity level (TUG p = .008, STS p = .001, FISH p = .006). Improvements in proprioception and physical activity level were greater in the SG compared to the other two groups (p < .05).
Compared to conventional exercise, the structured exercise protocol consisting of CKC exercise training produced improvements in proprioception and physical activity in patients with hemophilia A.
患有血友病 A 的患者，膝关节本体感觉会随时间推移而受损，下肢功能也会下降。
研究一种由闭链运动（CKC）练习组成的结构化运动方案对儿科血友病患者本体感觉和身体活动水平的影响。
共纳入 21 例至少有一个靶膝关节的血友病 A 患者，随机分为三组：研究组（SG，n=7）、常规治疗组（CTG，n=7）和对照组（CG，n=7）。SG 接受一种结构化的、下肢特异性的运动方案，包括每周 2 天进行 CKC 练习，持续 12 周，同时接受预防治疗。CTG 接受文献中描述的运动训练。CG 在研究期间继续接受预防治疗。在开链和闭链运动位置（CKCP）下，使用数字量角器在治疗前后测量本体感觉。五次坐下站起（STS）、计时起立行走（TUG）和血友病功能独立性评分用于评估身体活动水平。
治疗前后，各组之间的本体感觉（p=0.001）和身体活动水平（TUG p=0.008，STS p=0.001，FISH p=0.006）均有显著差异。与其他两组相比，SG 组的本体感觉和身体活动水平改善更为显著（p<0.05）。
与常规运动相比，由 CKC 运动训练组成的结构化运动方案可改善血友病 A 患者的本体感觉和身体活动水平。
