College of Veterinary Medicine and Bio-Safety Research Institute, Jeonbuk National University, Iksan, Republic of Korea.
College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Republic of Korea.
J Vet Med Sci. 2022 Sep 21;84(10):1358-1362. doi: 10.1292/jvms.21-0347. Epub 2022 Aug 2.
A 3-year-old female Miniature Schnauzer dog with a week-long history of generalized intention tremor and progressive weight loss for several months was admitted. Mild anemia, fever, splenomegaly, aseptic cerebral meningitis and systemic lymph nodes enlargement were examined through erythrogram, ultrasonography, computed tomography and magnetic resonance imaging. Mycobacterium bovis was identified via molecular microbiology having the same molecular type as that of isolates from a cattle farm previously identified. However, the dog was raised in a city. The M. bovis had multidrug resistance (MDR)-bearing mutations in both katG and rpoB genes toward first-line antibiotics. To the best of our knowledge, this is the first report describing an MDR M. bovis infection of a dog in Korea.
一只 3 岁雌性迷你雪纳瑞犬，出现全身性意向震颤一周，且在过去几个月中逐渐消瘦。通过血常规、超声、计算机断层扫描和磁共振成像检查发现，该犬存在轻度贫血、发热、脾肿大、无菌性脑膜脑炎和全身淋巴结肿大。通过分子微生物学鉴定出牛分枝杆菌，其分子类型与先前从一个牛场分离出的菌株相同。然而，该犬是在城市中饲养的。该牛分枝杆菌对一线抗生素同时具有 katG 和 rpoB 基因的耐药（MDR）突变。据我们所知，这是在韩国首次报道的耐多药牛分枝杆菌感染犬病例。
