Delhumeau A, Cottineau C, Jacob J P, Cocaud J, Granry J C, Cavellat M
Ann Fr Anesth Reanim. 1987;6(2):79-82. doi: 10.1016/s0750-7658(87)80107-7.
The haemodynamic changes due to cross-clamping of the abdominal aorta below the renal arteries were studied in ten patients. Anaesthesia was induced with thiopentone and maintained with fentanyl and vecuronium and inhalation of 60% nitrous oxide in oxygen. At the fifth minute, clamping increased mean arterial pressure (Pa) by 11%, systemic vascular resistance (Rsa) by 26% and decreased cardiac output (CO) by 20%. Nifedipine was administered intranasally at this time. Heart rate remained unchanged; mean pulmonary arterial and mean pulmonary wedge pressures were slightly decreased. Pa and Rsa fell to significantly lower levels between the fifth and fifteenth minutes (24 and 43% respectively). Although CO increased by 28%, this was not significant. The administration of intranasal nifedipine during anaesthesia was well tolerated. This study demonstrated that intranasal nifedipine prevented adverse haemodynamic effects of cross-clamping of the aorta below the renal arteries.
对10例患者进行了肾动脉以下腹主动脉交叉钳夹引起的血流动力学变化的研究。采用硫喷妥钠诱导麻醉，并用芬太尼、维库溴铵维持麻醉，同时吸入60%氧化亚氮和氧气。在第5分钟时，钳夹使平均动脉压（Pa）升高11%，全身血管阻力（Rsa）升高26%，心输出量（CO）降低20%。此时经鼻给予硝苯地平。心率保持不变；平均肺动脉压和平均肺楔压略有下降。在第5至15分钟之间，Pa和Rsa显著降至较低水平（分别为24%和43%）。虽然CO升高了28%，但无统计学意义。麻醉期间经鼻给予硝苯地平耐受性良好。本研究表明，经鼻给予硝苯地平可预防肾动脉以下主动脉交叉钳夹的不良血流动力学效应。
