Adachi Akiko, Oike Takahiro, Tamura Masaaki, Ota Norichika, Ohno Tatsuya
Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, JPN.
Heavy Ion Medical Center, Gunma University, Maebashi, JPN.
Cureus. 2022 Jul 29;14(7):e27464. doi: 10.7759/cureus.27464. eCollection 2022 Jul.
Sebaceous carcinoma is a rare and aggressive malignant tumor deriving from the adnexal epithelium of the sebaceous glands. The case of inoperable preauricular sebaceous carcinoma treated with definitive radiotherapy is first reported herein. Radiotherapy of 60 Gy in 30 fractions was combined with a hydrogen peroxide-soaked gauze bolus aiming at potential radiosensitization. Macroscopic complete remission was achieved eight months after radiotherapy with tolerable adverse effects. Although further clinical studies are needed, radiotherapy with a hydrogen peroxide-soaked gauze bolus can be an effective and tolerable treatment for inoperable patients with extraocular sebaceous carcinoma.
皮脂腺癌是一种罕见的侵袭性恶性肿瘤，起源于皮脂腺的附属器上皮。本文首次报道了采用根治性放疗治疗无法手术切除的耳前皮脂腺癌的病例。30次分割给予60 Gy的放疗，并联合用过氧化氢浸泡的纱布敷块，旨在实现潜在的放射增敏作用。放疗8个月后实现了宏观完全缓解，且不良反应可耐受。尽管还需要进一步的临床研究，但用过氧化氢浸泡的纱布敷块进行放疗对于无法手术的眼外皮脂腺癌患者可能是一种有效且可耐受的治疗方法。
