Peart W S
Contrib Nephrol. 1978;12:5-15. doi: 10.1159/000401649.
Renin release is believed to depend more on vasodilatation in the afferent arteriole than on any other factor. This allows for opposing effects of vasoconstriction and vasodilatation produced by sympathetic nerve stimulation by drugs or by autoregulation, to be interpreted in relation to the study of stretch of the afferent arteriole. This reduces but does not remove the necessity for alternate control through the macula densa. A final common pathway for all these stimuli is suggested through alterations in net calcium flux in the juxtaglomerular cell where increased intracellular calcium inhibits, and decreased intracellular calcium increases, renin release.
肾素释放被认为更多地取决于入球小动脉的血管舒张，而非其他任何因素。这使得药物引起的交感神经刺激或自身调节所产生的血管收缩和血管舒张的相反作用，能够根据入球小动脉牵张的研究来进行解释。这减少了但并未消除通过致密斑进行交替控制的必要性。通过球旁细胞净钙通量的改变提示了所有这些刺激的最终共同途径，即细胞内钙增加会抑制肾素释放，而细胞内钙减少则会增加肾素释放。
