干性与长期治疗的湿性年龄相关性黄斑变性中视神经乳头及视网膜神经节细胞的形态学与功能评估
Morphological and Functional Assessment of the Optic Nerve Head and Retinal Ganglion Cells in Dry vs Chronically Treated Wet Age-Related Macular Degeneration.
作者信息
Wichrowska Małgorzata, Wichrowski Przemysław, Kocięcki Jarosław
机构信息
Department of Ophthalmology, Poznan University of Medical Sciences, Poznań, Poland.
Doctoral School, Poznan University of Medical Sciences, Poznań, Poland.
出版信息
Clin Ophthalmol. 2022 Jul 28;16:2373-2384. doi: 10.2147/OPTH.S372626. eCollection 2022.
PURPOSE
The aim of the study comprised the anatomical and functional assessment of the optic nerves and macular ganglion cells in the population of patients with unilateral wet age-related macular degeneration (wAMD) and comparison of its results to those obtained from the fellow eye with non-advanced dry age-related macular degeneration (dAMD). Furthermore, we aimed to determine if the number of administered injections contributed to the potential differences between the examined eyes.
METHODS
The study was based on 104 eyes of 52 patients in a cross-sectional study. The eyes with chronically treated wAMD were the main subject of the study, while fellow eyes affected with non-advanced dAMD served as the control group. Primary morphological outcomes comprised differences in peripapillary retinal nerve fiber layer (RNFL) and GCC layers between the studied groups (treated and control). In turn, primary functional outcomes included differences in implicit times and amplitudes of the P100 wave of pattern visual evoked potentials (PVEP) and N95 wave of pattern electroretinogram (PERG) between treated and control groups.
RESULTS
We did not find any differences in total RNFL thickness between wAMD and dAMD groups. The number of injections only affected the RNFL in the nasal quadrant of the optic disc (p = 0.023). We did not find any differences regarding GCL thickness in both groups. In the study group, a longer implicit time of the P100 of PVEP (p = 0.014) and a shorter amplitude of the P50-N95 wave of PERG (p = 0.005) were detected. The total number of injections had no significant effect on these two values.
CONCLUSION
We detected worse functional parameters of the optic nerve and retinal ganglion cells in eyes with wAMD, with lack of significant differences in anatomical (RNFL, GCL) parameters compared to the control group. However, the number of injections did not contribute to the differences found.
目的
本研究旨在对单侧湿性年龄相关性黄斑变性（wAMD）患者的视神经和黄斑神经节细胞进行解剖学和功能评估，并将结果与对侧患有非进展性干性年龄相关性黄斑变性（dAMD）的眼睛的结果进行比较。此外，我们旨在确定注射次数是否导致了被检查眼睛之间的潜在差异。
方法
本研究为横断面研究，基于52例患者的104只眼睛。长期接受治疗的wAMD眼睛是主要研究对象，而患有非进展性dAMD的对侧眼睛作为对照组。主要形态学结果包括研究组（治疗组和对照组）之间视乳头周围视网膜神经纤维层（RNFL）和神经节细胞复合体（GCC）层的差异。相应地，主要功能结果包括治疗组和对照组之间图形视觉诱发电位（PVEP）P100波的潜伏期和振幅以及图形视网膜电图（PERG）N95波的差异。
结果
我们未发现wAMD组和dAMD组之间RNFL总厚度存在差异。注射次数仅对视盘鼻侧象限的RNFL有影响（p = 0.023）。我们未发现两组之间GCL厚度存在差异。在研究组中，检测到PVEP的P100潜伏期更长（p = 0.014）以及PERG的P50 - N95波振幅更短（p = 0.005）。注射总次数对这两个值没有显著影响。
结论
我们检测到wAMD眼睛的视神经和视网膜神经节细胞功能参数较差，与对照组相比，解剖学（RNFL、GCL）参数无显著差异。然而，注射次数并未导致所发现的差异。
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