Li An-Hai, Li Wen-Wen, Yu Xiao-Qian, Zhang Dai-Ming, Liu Yi-Ran, Li Ding
Department of Dermatology, Qingdao Huangdao District Central Hospital, Qingdao, People's Republic of China.
Department of Hematology, Qingdao Women and Children's Hospital, Qingdao, People's Republic of China.
Clin Cosmet Investig Dermatol. 2022 Jul 28;15:1447-1458. doi: 10.2147/CCID.S378143. eCollection 2022.
Psoriasis is a recurrent, chronic, inflammation- and immune-mediated skin disease with multiple causative factors. However, the genetic markers associated with recurrence have not yet been fully elucidated. Accordingly, in this study, we aimed to identify markers associated with the recurrence of psoriasis.
We analyzed differentially expressed genes to determine which targets were associated with the recurrence of psoriasis and used these data to construct a protein-protein interaction network using Cytoscape software. The results were then validated by analysis of core targets using Gene Expression Omnibus (GEO) datasets and clinical samples. Functional enrichment analysis was used to explore the potential mechanisms mediating the recurrence of psoriasis.
We screened out six core targets that played important roles in recurrence of psoriasis, and validation of GEO datasets and clinical samples showed that the expression levels of five core targets were higher in patients with psoriasis than in healthy individuals. Functional enrichment analysis revealed that the cell cycle and oocyte meiosis signaling pathways were involved in the recurrence of psoriasis.
Our findings provided insights into the mechanisms mediating the onset and recurrence of psoriasis.
银屑病是一种由多种致病因素引起的复发性、慢性、炎症和免疫介导的皮肤病。然而，与复发相关的遗传标记尚未完全阐明。因此，在本研究中，我们旨在确定与银屑病复发相关的标记。
我们分析差异表达基因以确定哪些靶点与银屑病复发相关，并使用这些数据通过Cytoscape软件构建蛋白质-蛋白质相互作用网络。然后通过使用基因表达综合数据库（GEO）数据集和临床样本对核心靶点进行分析来验证结果。功能富集分析用于探索介导银屑病复发的潜在机制。
我们筛选出六个在银屑病复发中起重要作用的核心靶点，GEO数据集和临床样本的验证表明，五个核心靶点在银屑病患者中的表达水平高于健康个体。功能富集分析显示细胞周期和卵母细胞减数分裂信号通路参与了银屑病的复发。
我们的研究结果为介导银屑病发病和复发的机制提供了见解。
