Hospital Pharmacy, Tjongerschans Hospital Heerenveen, Heerenveen, The Netherlands.
Department of Clinical Pharmacy, OLVG Hospital, Amsterdam, The Netherlands.
J Clin Pharm Ther. 2022 Sep;47(9):1444-1451. doi: 10.1111/jcpt.13724. Epub 2022 Aug 3.
Many severe intoxications occur with substances with no specific antidote, which is why methods of extracorporeal elimination represent a particularly useful and even critical component in their management. The purpose of this review is to summarize the accumulating evidence and clinical results from the application of CytoSorb hemoadsorption therapy in patients with severe intoxications.
The technology represents a promising technique with an increasing number of publications in a variety of severe intoxication scenarios suggesting that early intervention might provide rapid substance removal with subsequent overall clinical improvement.
Given the tremendous challenges in performing prospective, randomized trials in this field, the strong safety profile of the device and the high acuity of these life-threatening situations, CytoSorb should be considered as a therapeutic option in severe intoxications, particularly when direct antidotes are not available. However, further clinical data are desirable to provide precise recommendations.
许多严重中毒的发生与没有特定解毒剂的物质有关，因此体外清除方法在其治疗中是一个特别有用甚至关键的组成部分。本综述的目的是总结 CytoSorb 血液吸附疗法在严重中毒患者中的应用的累积证据和临床结果。
该技术是一种很有前途的技术，在各种严重中毒情况下的出版物越来越多，这表明早期干预可能会提供快速的物质清除，随后整体临床改善。
鉴于在该领域进行前瞻性、随机试验存在巨大挑战，以及该设备具有极高的安全性和这些危及生命的严重中毒情况的高发病率，CytoSorb 应被视为严重中毒的治疗选择，特别是当没有直接解毒剂时。然而，需要进一步的临床数据来提供精确的建议。
