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肺移植中的肺灌注

Lung Perfusion in Lung Transplantation.

作者信息

Haam Seokjin

机构信息

Department of Thoracic and Cardiovascular Surgery, Ajou University School of Medicine, Suwon, Korea.

出版信息

J Chest Surg. 2022 Aug 5;55(4):288-292. doi: 10.5090/jcs.22.056.

DOI:10.5090/jcs.22.056
PMID:35924535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9358162/
Abstract

lung perfusion (EVLP) is a technique that enables active metabolism of the lung by creating an environment similar to that inside the body, even though the explanted lungs are outside the body. The EVLP system enables the use of lung grafts that do not satisfy the acceptance criteria for lung transplantation (LTx) by making it possible to evaluate the function of the lung grafts and repair lungs in poor condition, thereby reducing the waiting time of patients requiring LTx and consequently mortality.

摘要

体外肺灌注（EVLP）是一种通过创造与体内环境相似的条件，使离体肺能够进行活跃代谢的技术，尽管这些肺已不在体内。EVLP系统能够评估肺移植供肺的功能，并修复状况不佳的肺，从而使原本不符合肺移植（LTx）接受标准的供肺得以使用，进而缩短LTx患者的等待时间，降低死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d1/9358162/c1ddcce60469/jcs-55-4-288-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d1/9358162/e0ca771bcc1c/jcs-55-4-288-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d1/9358162/c1ddcce60469/jcs-55-4-288-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d1/9358162/e0ca771bcc1c/jcs-55-4-288-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d1/9358162/c1ddcce60469/jcs-55-4-288-f2.jpg

相似文献

1
Lung Perfusion in Lung Transplantation.肺移植中的肺灌注
J Chest Surg. 2022 Aug 5;55(4):288-292. doi: 10.5090/jcs.22.056.
2
Outcomes of marginal donors for lung transplantation after ex vivo lung perfusion: A systematic review and meta-analysis.体外肺灌注后边缘供体肺移植的结果：系统评价和荟萃分析。
J Thorac Cardiovasc Surg. 2020 Feb;159(2):720-730.e6. doi: 10.1016/j.jtcvs.2019.07.087. Epub 2019 Aug 25.
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Early results in transplantation of initially rejected donor lungs after ex vivo lung perfusion: a case-control study.体外肺灌注后最初被排斥的供体肺移植的早期结果：一项病例对照研究。
Eur J Cardiothorac Surg. 2014 Jan;45(1):40-4; discussion 44-5. doi: 10.1093/ejcts/ezt250. Epub 2013 May 10.
4
Ten year follow-up of lung transplantations using initially rejected donor lungs after reconditioning using ex vivo lung perfusion.使用体外肺灌注进行修复后最初被拒绝的供体肺进行肺移植的十年随访。
J Cardiothorac Surg. 2019 Jul 1;14(1):125. doi: 10.1186/s13019-019-0948-1.
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Treatment with 3-aminobenzamide during ex vivo lung perfusion of damaged rat lungs reduces graft injury and dysfunction after transplantation.在受损大鼠肺的体外肺灌注过程中用 3-氨基苯甲酰胺进行治疗可减少移植后移植物损伤和功能障碍。
Am J Transplant. 2020 Apr;20(4):967-976. doi: 10.1111/ajt.15695. Epub 2019 Dec 4.
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An observational study of Donor Ex Vivo Lung Perfusion in UK lung transplantation: DEVELOP-UK.英国肺移植中供体体外肺灌注的观察性研究：DEVELOP-UK。
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Ex vivo lung perfusion: a potential platform for molecular diagnosis and organ repair.体外肺灌注：分子诊断与器官修复的潜在平台。
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Predicting donor lung acceptance for transplant during ex vivo lung perfusion: The EX vivo lung PerfusIon pREdiction (EXPIRE).在体外肺灌注过程中预测供肺移植的接受情况：体外肺灌注预测（EXPIRE）。
Am J Transplant. 2021 Nov;21(11):3704-3713. doi: 10.1111/ajt.16616. Epub 2021 Jun 11.

引用本文的文献

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Use of Ex-Vivo Lung Perfusion for Planned Left Single-Lung Transplant.体外肺灌注在计划性左侧单肺移植中的应用
Ann Thorac Surg Short Rep. 2024 Aug 6;3(1):247-249. doi: 10.1016/j.atssr.2024.07.025. eCollection 2025 Mar.
2
The impact and relevance of techniques and fluids on lung injury in machine perfusion of lungs.技术和液体对肺机器灌注中肺损伤的影响和相关性。
Front Immunol. 2024 Mar 6;15:1358153. doi: 10.3389/fimmu.2024.1358153. eCollection 2024.

本文引用的文献

1
Prone ex vivo lung perfusion protects human lungs from reperfusion injury.俯卧位离体肺灌注可保护人体肺免受再灌注损伤。
Artif Organs. 2022 Nov;46(11):2226-2233. doi: 10.1111/aor.14328. Epub 2022 Jun 11.
2
OPTN/SRTR 2018 Annual Data Report: Lung.OPTN/SRTR 2018 年度数据报告：肺。
Am J Transplant. 2020 Jan;20 Suppl s1:427-508. doi: 10.1111/ajt.15677.
3
Normothermic ex vivo lung perfusion: Does the indication impact organ utilization and patient outcomes after transplantation?常温体外肺灌注：适应证是否会影响移植后的器官利用及患者预后？
J Thorac Cardiovasc Surg. 2020 Jan;159(1):346-355.e1. doi: 10.1016/j.jtcvs.2019.06.123. Epub 2019 Sep 9.
4
Mesenchymal stromal cell therapy during ex vivo lung perfusion ameliorates ischemia-reperfusion injury in lung transplantation.间质基质细胞治疗在体外肺灌注中改善肺移植中的缺血再灌注损伤。
J Heart Lung Transplant. 2019 Nov;38(11):1214-1223. doi: 10.1016/j.healun.2019.07.006. Epub 2019 Jul 26.
5
Hydrogen gas inhalation during ex vivo lung perfusion of donor lungs recovered after cardiac death.在心脏死亡后恢复的供肺的离体肺灌注期间吸入氢气。
J Heart Lung Transplant. 2018 Oct;37(10):1271-1278. doi: 10.1016/j.healun.2018.06.007. Epub 2018 Jun 21.
6
Accumulation and cellular localization of nanoparticles in an ex vivo model of acute lung injury.纳米颗粒在急性肺损伤离体模型中的积累及细胞定位
J Surg Res. 2017 Apr;210:78-85. doi: 10.1016/j.jss.2016.11.007. Epub 2016 Nov 9.
7
Safety and Efficacy of Ex Vivo Donor Lung Adenoviral IL-10 Gene Therapy in a Large Animal Lung Transplant Survival Model.供体肺腺病毒 IL-10 基因治疗在大型动物肺移植存活模型中的安全性和疗效。
Hum Gene Ther. 2017 Sep;28(9):757-765. doi: 10.1089/hum.2016.070. Epub 2017 Jan 4.
8
Lung Lavage and Surfactant Replacement During Ex Vivo Lung Perfusion for Treatment of Gastric Acid Aspiration-Induced Donor Lung Injury.肺灌洗和表面活性剂替代在体外肺灌注治疗胃酸吸入性供肺损伤中的应用。
J Heart Lung Transplant. 2017 May;36(5):577-585. doi: 10.1016/j.healun.2016.11.010. Epub 2016 Dec 1.
9
Machine perfusion in liver transplantation as a tool to prevent non-anastomotic biliary strictures: Rationale, current evidence and future directions.机器灌注在肝移植中作为预防非吻合胆道狭窄的工具：原理、当前证据和未来方向。
J Hepatol. 2015 Jul;63(1):265-75. doi: 10.1016/j.jhep.2015.03.008. Epub 2015 Mar 12.
10
Successful lung transplantation after donor lung reconditioning with urokinase in ex vivo lung perfusion system.在体外肺灌注系统中使用尿激酶对供体肺进行预处理后成功进行肺移植。
Ann Thorac Surg. 2014 Nov;98(5):1837-8. doi: 10.1016/j.athoracsur.2014.01.076. Epub 2014 Oct 30.