College of Chemistry and Chemical Engineering, Anhui University and Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials, Anhui University, Ministry of Education, Hefei 230601, P. R. China.
First Clinical Medical College of Anhui Medical University, Hefei 230601, P. R. China.
ACS Appl Mater Interfaces. 2022 Aug 17;14(32):36438-36450. doi: 10.1021/acsami.2c09419. Epub 2022 Aug 4.
The pursuit of mesoporous Fe-based nanoagents addresses the field of developing alternative Fe-bearing nanoagents for synergistic cancer therapy with the expectation that the use of an essential element may avoid the issues raised by the exogenous administration of other metal element-based nanoagents. Herein, we highlight the interface-engineered mesoporous () where the core is interfacially oxidized into an FeOOH nanosheet loaded with the chemotherapeutic drug doxorubicin (DOX) and further encapsuled within the double-sulfide-bonded SiO outer layer, denoted as , which can realize programmed drug release for synergistic cancer theranostics. When only in a tumor microenvironment, the nanoagent can be activated to release DOX from the and FeOOH nanosheets as well as expose the easily oxidized to spontaneously transform to FeOOH nanosheets with Fenton activity to facilitate chemodynamic therapy (CDT). In addition, the high photothermal conversion efficiency of would promote CDT. Also, owing to the inherent nature of ferromagnetism and red fluorescence of DOX, can realize T2-weighted magnetic resonance imaging and fluorescence imaging. In vivo mouse model experiments demonstrate that with good biocompatibility realizing CDT/photothermal therapy/chemotherapy achieved complete tumor suppression. This study opens up a new way to explore theranostic nanoagents.
介孔 Fe 基纳米制剂的研究旨在开发替代含 Fe 纳米制剂用于协同癌症治疗，期望使用必需元素避免外源性添加其他金属元素纳米制剂带来的问题。在此，我们重点介绍界面工程化的介孔 （），其中核心 被界面氧化成负载化疗药物阿霉素（DOX）的 FeOOH 纳米片，并进一步封装在双硫键合 SiO 外层内，记为 ，它可以实现程序化药物释放以用于协同癌症治疗。只有在肿瘤微环境中，纳米制剂才能被激活，从 和 FeOOH 纳米片中释放 DOX，并暴露出易于氧化的 ，从而自发转化为具有 Fenton 活性的 FeOOH 纳米片以促进化学动力学治疗（CDT）。此外， 的高光热转换效率也会促进 CDT。此外，由于 DOX 的顺磁性和红色荧光的固有特性， 可以实现 T2 加权磁共振成像和荧光成像。体内小鼠模型实验表明，具有良好生物相容性的 ，实现了 CDT/光热治疗/化疗，完全抑制了肿瘤。这项研究为探索治疗性纳米制剂开辟了新途径。
