Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India.
Org Lett. 2022 Aug 19;24(32):6078-6082. doi: 10.1021/acs.orglett.2c02442. Epub 2022 Aug 4.
Base promoted one-pot annulative coupling of 1,2,3,4-tetrahydroisoquinolines (THIQs) with hypervalent iodine(III) species aryliodonio diazo compounds has been devised for the direct construction of 1,2,4-triazolo[3,4-]isoquinoline derivatives at room temperature in open air for the first time. This approach involves [2 + 3] cascade annulation of nucleophilic THIQ with an electrophilic aryliodonio diazo compound via N-H and α-C1(sp)-H difunctionalization of THIQ.
首次在室温、开放条件下，通过 1,2,3,4-四氢异喹啉（THIQ）与高价碘（III）物种芳基碘代重氮化合物的一锅法环合反应，构建了 1,2,4-三唑并[3,4-]异喹啉衍生物。该方法涉及亲核 THIQ 与亲电芳基碘代重氮化合物通过 THIQ 的 N-H 和 α-C1（sp）-H 双官能化的[2 + 3]级联环合。
