食管鳞癌中的癌症干细胞。

Cancer stem cells in esophageal squamous cell carcinoma.

机构信息

State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi'an, China.

Graduate School, Fourth Military Medical University, Xi'an, China.

出版信息

Pathol Res Pract. 2022 Sep;237:154043. doi: 10.1016/j.prp.2022.154043. Epub 2022 Jul 30.

DOI:10.1016/j.prp.2022.154043

PMID:35926434

Abstract

Esophageal squamous cell carcinoma (ESCC) is one of the most intractable challenges among human diseases with poor prognosis and shortness of effective therapeutic options. Cancer stem cells (CSCs), a tumor sub-population, are considered the cause of tumor growth, differentiation, metastasis and therapeutic resistance, etc. In this review, we discuss the known methods for isolation and verification of ESCC CSCs, the biomarkers of ESCC CSCs and their significance in diagnosis and prognosis. Then we review the ESCC CSC signaling pathway and therapeutic resistance. In pace with the detailed studies of ESCC CSCs increasing, treatment strategies of ESCC based on CSCs are becoming more promising.

摘要

食管鳞状细胞癌（ESCC）是人类疾病中最棘手的挑战之一，预后不良，有效治疗选择有限。癌症干细胞（CSC）是肿瘤亚群的一种，被认为是肿瘤生长、分化、转移和治疗耐药等的原因。在这篇综述中，我们讨论了 ESCC CSC 的已知分离和验证方法、ESCC CSC 的生物标志物及其在诊断和预后中的意义。然后，我们回顾了 ESCC CSC 信号通路和治疗耐药性。随着对 ESCC CSC 的详细研究的增加，基于 CSC 的 ESCC 治疗策略越来越有前途。