Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA; Neuroscience Graduate Program, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA; Cell and Molecular Biology Training Program, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Neuron. 2022 Aug 3;110(15):2356-2358. doi: 10.1016/j.neuron.2022.06.015.
NLRP3 is a central driver of neurodegeneration thought to function mainly in microglia. In this issue of Neuron, Panicker et al. (2022) find that NLRP3 is a parkin substrate that contributes significantly to Parkinson's disease pathogenesis by acting in neurons.
NLRP3 是神经退行性变的主要驱动因素，被认为主要在小胶质细胞中发挥作用。在本期《神经元》杂志中，Panicker 等人（2022 年）发现 NLRP3 是 parkin 的底物，通过在神经元中发挥作用，对帕金森病的发病机制有重要贡献。
