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2022 年睾丸生殖细胞肿瘤分期的更新。

Updates in 2022 on the staging of testicular germ cell tumors.

机构信息

Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.

Department of Urology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, 35233, USA; Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.

出版信息

Hum Pathol. 2022 Oct;128:152-160. doi: 10.1016/j.humpath.2022.07.009. Epub 2022 Aug 1.

Abstract

Testicular cancer is the most common solid neoplasm of adult men between the ages of 20 and 40 years. Germ cell tumors account for 95% of all testicular tumors. The assessment of staging is essential to guide further management of patients with testicular cancer and to prognosticate cancer-related outcomes. Postradical orchiectomy treatment options, including adjuvant therapy and active surveillance, vary based on the anatomical extent of disease, serum tumor markers, pathologic diagnosis, and imaging. This review provides an update on the germ cell tumor staging system adopted by the 8th edition of the American Joint Commission on Cancer (AJCC) Staging Manual, treatment implications, risk factors, and predictors of outcomes.

摘要

睾丸癌是 20 至 40 岁男性中最常见的成人实体瘤。生殖细胞肿瘤占所有睾丸肿瘤的 95%。分期评估对于指导睾丸癌患者的进一步治疗和预测癌症相关结局至关重要。根治性睾丸切除术的治疗选择,包括辅助治疗和主动监测,取决于疾病的解剖范围、血清肿瘤标志物、病理诊断和影像学。本文综述了第 8 版美国癌症联合委员会(AJCC)分期手册采用的生殖细胞肿瘤分期系统的更新、治疗意义、危险因素和预后预测因素。

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