Wakita K, Kuramoto H, Sasaki N, Ushiki N
Gan To Kagaku Ryoho. 1987 May;14(5 Pt 2):1501-7.
We performed laser therapy for cervical neoplasia as a conservative therapy. Our materials were 202 cases (dysplasia-166, carcinoma in situ-36) treated by laser vaporization and 31 cases (dysplasia-7, CIS-7, questionable microinvasive cancer-17) by laser incisional conization. In addition to CO2 laser, we developed YAG laser and YAG/CO2 coaxial simultaneous laser for laser vaporization. On the other hand, we applied YAG laser for incisional conization with an attached laser rod (made of new ceramics) for use on an outpatient basis without anesthesia. Total cure rate after first treatment with laser vaporization was 93.0% (dysplasia 93.3%, CIS-91.7%). Pathological examination of the cone specimen revealed 8 cases of invasion (Ia stage-7, Ib stage-1). No abnormal findings could be found in follow-up cases. Complications were minimal in all cases. We thus demonstrated that simple and individualized management was possible for cervical neoplasia by applying either of these new methods.
我们采用激光治疗作为宫颈肿瘤的保守治疗方法。我们的治疗对象包括202例采用激光汽化治疗的患者（发育异常166例，原位癌36例）以及31例采用激光切除锥形活检术治疗的患者（发育异常7例，原位癌7例，可疑微小浸润癌17例）。除二氧化碳激光外，我们还研发了用于激光汽化的钇铝石榴石激光以及钇铝石榴石/二氧化碳同轴同步激光。另一方面，我们将钇铝石榴石激光应用于切除锥形活检术，使用一种附在新型陶瓷制成的激光棒上的方法，无需麻醉即可在门诊进行。首次激光汽化治疗后的总治愈率为93.0%（发育异常93.3%，原位癌91.7%）。锥形标本的病理检查显示有8例浸润（Ia期7例，Ib期1例）。随访病例未发现异常情况。所有病例的并发症都很少。因此，我们证明了通过应用这些新方法中的任何一种，都可以对宫颈肿瘤进行简单且个体化的治疗。
