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[胃癌和乳腺癌的术前放疗]

[Preoperative radiotherapy of carcinoma of the stomach and breast].

作者信息

Kamimura S, Mikuriya S, Hara O, Nakasa T, Tamura Y, Akiyama M, Kawai S, Asano A

出版信息

Gan To Kagaku Ryoho. 1987 May;14(5 Pt 2):1558-63.

PMID:3592699
Abstract

Sixty-one patients with gastric cancer and thirty-seven with breast cancer who had undergone preoperative radiotherapy were analysed retrospectively for assessment of various radiotherapeutic effects and prognosis. Most of the sixty-one patients with gastric cancer were found to be stage III or more with borderline operable lesions on admission. Of the sixty-one patients, sixteen were evaluated postoperatively to be stage I by histopathological examination. The 3-year survival rate in these sixteen patients was an admirable 60%. Of the thirty-seven patients with breast cancer, the 3-year survival rate among twenty-four in Stage III exceeded 90%. This survival rate is very high in comparison with other reports. For radiotherapy we adopted a less-fractionated irradiation method with a large dose instead of the conventional fractionated one. This irradiation method has not only a direct radiotherapeutic effect, but also produces a favorable effect on the host's immunocompetence. For gastric cancer, twice weekly treatment with 5 Gy and 3 Gy per week, and irradiation twice with 20 Gy and 10 Gy for breast cancer were very suitable preoperative irradiation doses.

摘要

对61例接受术前放疗的胃癌患者和37例接受术前放疗的乳腺癌患者进行回顾性分析,以评估各种放疗效果和预后。61例胃癌患者中,大多数入院时被发现为III期或更晚期,病变为临界可切除。61例患者中,16例术后经组织病理学检查评估为I期。这16例患者的3年生存率高达60%,令人钦佩。37例乳腺癌患者中,24例III期患者的3年生存率超过90%。与其他报告相比,这个生存率非常高。对于放疗,我们采用了大剂量少分割照射方法,而不是传统的分割照射方法。这种照射方法不仅有直接的放疗效果,而且对宿主的免疫能力也有良好影响。对于胃癌,每周5 Gy、每周3 Gy的每周两次治疗,以及对于乳腺癌20 Gy和10 Gy的两次照射是非常合适的术前照射剂量。

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