Jimbow T, Tejima Y, Ikemoto H
Chemotherapy. 1978;24(6):374-89. doi: 10.1159/000237811.
Therapeutic effectiveness of 5-fluorocytosine (5-FC), amphotericin B (Am B) and both in combined administration were retrospectively assessed and compared with one another in 28 patients with cryptococcal meningitis. Combined administration was significantly superior to Am B alone and to 5-FC alone, and these agents were suggested to afford a synergetic effect in combined administration. Adverse reactions associated with combined administration did not essentially differ from those with Am B or 5-FC alone. Combined administration was able to decrease the incidence and severity of adverse reactions by employing lower doses of Am B, and this combined administration reduced the duration of treatment. An appropriate dose for each agent in combined administration was deemed to be about 0.350 mg/kg/day Am B i.v. and 150 mg/kg/day 5-FC p. o. based on the results of this study.
回顾性评估了28例隐球菌性脑膜炎患者使用5-氟胞嘧啶（5-FC）、两性霉素B（Am B）以及二者联合给药的治疗效果，并进行相互比较。联合给药显著优于单独使用Am B和单独使用5-FC，提示这些药物联合使用具有协同效应。联合给药相关的不良反应与单独使用Am B或5-FC时基本无差异。联合给药通过使用较低剂量的Am B能够降低不良反应的发生率和严重程度，且这种联合给药缩短了治疗时间。基于本研究结果，联合给药时每种药物的合适剂量被认为是静脉注射Am B约0.350 mg/kg/天和口服5-FC 150 mg/kg/天。
