She D Y
Zhonghua Jie He He Hu Xi Za Zhi. 2022 Aug 12;45(8):733-735. doi: 10.3760/cma.j.cn112147-20220530-00464.
Pseudomonas aeruginosa is one of the most important pathogens causing chronic lower respiratory tract infections in patients with chronic lung diseases such as cystic fibrosis, bronchiectasis and chronic obstructive pulmonary disease. The poor prognosis of these diseases has been found to be associated with chronic Pseudomonas aeruginosa infection in lower respiratory tract, which can be a consequence or a cause of the disease progression depending on different circumstances. Optimizing the management of chronic Pseudomonas aeruginosa infection is of great significance to improve the prognosis of these chronic lung diseases. Unlike the therapy of acute pneumonia due to Pseudomonas aeruginosa, the goals of the management for chronic Pseudomonas aeruginosa infection are not only to control infection, but also to reduce symptoms, prevent exacerbations, stop the disease progression and improve the quality of life. In addition to systemic anti-pseudomonas therapy during exacerbations, long-term multiple measures including anti-inflammatory therapy, immunomodulatory therapy,airway clearance techniques, mucoactive therapy, etc. should also be given to the patients with chronic lower respiratory tract infection due to Pseudomonas aeruginosa.
铜绿假单胞菌是导致慢性肺部疾病（如囊性纤维化、支气管扩张和慢性阻塞性肺疾病）患者发生慢性下呼吸道感染的最重要病原体之一。已发现这些疾病的不良预后与下呼吸道慢性铜绿假单胞菌感染有关，根据不同情况，这可能是疾病进展的结果或原因。优化慢性铜绿假单胞菌感染的管理对于改善这些慢性肺部疾病的预后具有重要意义。与铜绿假单胞菌所致急性肺炎的治疗不同，慢性铜绿假单胞菌感染管理的目标不仅是控制感染，还包括减轻症状、预防病情加重、阻止疾病进展以及提高生活质量。除了在病情加重期间进行全身性抗假单胞菌治疗外，对于因铜绿假单胞菌引起慢性下呼吸道感染的患者，还应给予长期的多种措施，包括抗炎治疗、免疫调节治疗、气道廓清技术、黏液促排治疗等。
