Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Institute of Anesthesiology and critical care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Cytokine Growth Factor Rev. 2023 Feb;69:90-103. doi: 10.1016/j.cytogfr.2022.07.007. Epub 2022 Jul 21.
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. In sepsis, a complicated immune response is initiated, which varies over time with sustained excessive inflammation and immunosuppression. Identifying a promising way to orchestrate sepsis-induced immunosuppression is a challenge. Myeloid-derived suppressor cells (MDSCs) comprise pathologically activated neutrophils and monocytes with potent immunosuppressive activity. They play an important part in inhibiting innate and adaptive immune responses, and have emerged as part of the immune response in sepsis. MDSCs numbers are persistently high in sepsis patients, and associated with nosocomial infections and other adverse clinical outcomes. However, their characteristics and functional mechanisms during sepsis have not been addressed fully. Our review sheds light on the features and suppressive mechanism of MDSCs. We also review the potential applications of MDSCs as biomarkers and targets for clinical treatment of sepsis.
脓毒症是一种危及生命的器官功能障碍，由宿主对感染的失调反应引起。在脓毒症中，会引发复杂的免疫反应，其随时间推移而变化，持续存在过度炎症和免疫抑制。确定一种有前途的方法来协调脓毒症引起的免疫抑制是一项挑战。髓系来源的抑制细胞（MDSC）由具有强大免疫抑制活性的病理性激活的中性粒细胞和单核细胞组成。它们在抑制先天和适应性免疫反应中发挥重要作用，并已成为脓毒症免疫反应的一部分。脓毒症患者的 MDSC 数量持续升高，并与医院获得性感染和其他不良临床结局相关。然而，它们在脓毒症中的特征和功能机制尚未得到充分解决。我们的综述阐明了 MDSC 的特征和抑制机制。我们还综述了 MDSC 作为脓毒症临床治疗的生物标志物和靶点的潜在应用。
