Department of Gastroenterology, Xiang ya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University, Changsha, China.
Department of Gastroenterology, Yi yang Central Hospital, Yiyang, China.
Arab J Gastroenterol. 2023 Feb;24(1):16-23. doi: 10.1016/j.ajg.2022.05.004. Epub 2022 Aug 1.
The treatment approach for Crohn's disease (CD) is focused on mucosal healing and resolution of transmural inflammation. The aim of this study is to evaluate the correlation between computed tomography enterography (CTE) and other treatments, in particular, endoscopy and biochemical indicators, in newly diagnosed patients with CD.
One hundred twenty-three patients with CD who received CTE in Xiangya Hospital, Central South University, China, from April 2017 to April 2019 were included. The clinical case data and imaging results were retrospectively reviewed. The clinical activity of CD was determined by the Crohn's disease activity index (CDAI) score and biochemical indicators. The relationships between CTE and endoscopy, CDAI score, and inflammatory markers were evaluated.
The diagnostic rate of CTE of the 123CD patients was 68.3% (84/123). Logistic regression analysis showed that the specific CTE manifestations related to CD activity were intestinal wall stratification, comb sign, and abdominal abscesses (P < 0.05). Spearman's rank correlation analysis showed that inflammatory markers positively correlated with different CTE imaging manifestations.
Intestinal CTE combined with endoscopy and biochemical indicators is both comprehensive and effective in evaluating the condition of CD patients.
克罗恩病（CD）的治疗方法侧重于黏膜愈合和穿壁性炎症的消退。本研究旨在评估计算机断层扫描肠造影术（CTE）与其他治疗方法，特别是内镜和生化指标在新发 CD 患者中的相关性。
本研究纳入了 2017 年 4 月至 2019 年 4 月在中南大学湘雅医院接受 CTE 的 123 例 CD 患者。回顾性分析了患者的临床病例数据和影像学结果。CD 的临床活动度通过克罗恩病活动指数（CDAI）评分和生化指标来确定。评估了 CTE 与内镜、CDAI 评分和炎症标志物之间的关系。
123 例 CD 患者的 CTE 诊断率为 68.3%（84/123）。逻辑回归分析显示，与 CD 活动相关的特定 CTE 表现为肠壁分层、梳状征和腹腔脓肿（P<0.05）。Spearman 秩相关分析显示，炎症标志物与不同的 CTE 影像学表现呈正相关。
肠道 CTE 结合内镜和生化指标可全面有效地评估 CD 患者的病情。
