Southern California Eye Physicians & Surgeons, 1111 S. Fair Oaks Ave, Pasadena, CA, 91105, USA.
Center for Oculofacial & Orbital Surgery, 10861 Cherry Street #208, Los Alamitos, CA, 90720, USA.
J Med Case Rep. 2022 Aug 5;16(1):299. doi: 10.1186/s13256-022-03493-6.
Oxymetazoline hydrochloride ophthalmic solution (0.1%) is a medication used to treat blepharoptosis. Patients who suffer from blepharoptosis have low-lying eyelids that can hinder their vision. Oxymetazoline hydrochloride ophthalmic solution (0.1%) is prescribed to patients to improve their vision by lifting the upper eyelids. Blepharospasm consists of involuntary, bilateral orbicularis oculi muscle movements that result in twitching and eyelid closure. Botulinum toxin is a treatment used to treat blepharospasm by preventing muscle contraction; but it is not always effective.
The effects of treatment with both oxymetazoline hydrochloride ophthalmic solution (0.1%) and botulinum toxin are assessed in three patients: (1) Patient A, a 58-year-old Filipina woman; (2) patient B, a 62-year-old Korean woman; and (3) patient C, A 57-year-old Vietnamese woman. All patients had been diagnosed with blepharoptosis as well as blepharospasm. Each patient was given an opportunity to complete an optional survey to assess not only the efficacy of oxymetazoline hydrochloride ophthalmic solution (0.1%) together with botulinum toxin but also their perceived stress during the past month.
Administering botulinum toxin for the treatment of blepharospasm in patients A and B yielded the expected results; adding oxymetazoline hydrochloride ophthalmic solution (0.1%), a medical treatment for ptosis, to the treatment regimen yielded an unexpected reduction of blepharospasm. We propose that botulinum toxin and oxymetazoline hydrochloride ophthalmic solution (0.1%) can have a synergistic effect on reducing blepharospasm when used concomitantly. We present three cases in which combined use of botulinum toxin with oxymetazoline hydrochloride ophthalmic solution (0.1%) reduced blepharospasm, and propose possible reasons for such effects. We also discuss previous literature in agreement with the results of our cases.
盐酸羟甲唑啉滴眼液（0.1%）是一种用于治疗上睑下垂的药物。患有上睑下垂的患者眼睑低垂，可能会妨碍视力。盐酸羟甲唑啉滴眼液（0.1%）被开给患者，以通过提起上眼睑来改善视力。眼睑痉挛由不自主的双侧眼轮匝肌运动引起，导致抽搐和眼睑闭合。肉毒毒素是一种通过防止肌肉收缩来治疗眼睑痉挛的治疗方法；但它并不总是有效。
对 3 名患者（1）58 岁菲律宾女性患者 A；（2）62 岁韩国女性患者 B；和（3）57 岁越南女性患者 C）进行了盐酸羟甲唑啉滴眼液（0.1%）和肉毒毒素联合治疗效果的评估。所有患者均被诊断为上睑下垂和眼睑痉挛。每位患者都有机会完成一份可选的调查，以评估盐酸羟甲唑啉滴眼液（0.1%）联合肉毒毒素的疗效，以及他们过去一个月的感知压力。
在患者 A 和 B 中使用肉毒毒素治疗眼睑痉挛产生了预期的效果；在治疗方案中添加治疗上睑下垂的盐酸羟甲唑啉滴眼液（0.1%）产生了意外的眼睑痉挛减轻。我们提出，当同时使用时，肉毒毒素和盐酸羟甲唑啉滴眼液（0.1%）可以对减轻眼睑痉挛产生协同作用。我们提出了三个联合使用肉毒毒素和盐酸羟甲唑啉滴眼液（0.1%）减轻眼睑痉挛的病例，并提出了可能产生这种效果的原因。我们还讨论了与我们的病例结果一致的先前文献。
