Department of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.
Institute of Biochemistry and Cell Biology, National Council of Research (IBBC-CNR), Monterotondo (RM), Italy.
Curr Stem Cell Res Ther. 2023;18(4):440-444. doi: 10.2174/1574888X17666220802142532.
Smoking habits represent a cardiovascular risk factor with a tremendous impact on health. Other than damaging differentiated and functional cells of the cardiovascular system, they also negatively affect reparative mechanisms, such as those involved in cardiac fibrosis and in endothelial progenitor cell (EPC) activation. In recent years, alternative smoking devices, dubbed modified tobacco risk products (MRPs), have been introduced, but their precise impact on human health is still under evaluation. Also, they have not been characterized yet about the possible negative effects on cardiovascular reparative and regenerative cells, such as EPCs or pluripotent stem cells. In this perspective, we critically review the still scarce available data on the effects of MRPs on molecular and cellular mechanisms of cardiovascular repair and regeneration.
吸烟习惯是心血管疾病的一个危险因素，对健康有巨大影响。除了损害心血管系统的分化和功能细胞外，它们还会对修复机制产生负面影响，如心脏纤维化和内皮祖细胞（EPC）激活过程中的修复机制。近年来，出现了一种名为改良烟草风险产品（MRPs）的新型吸烟装置，但它们对人体健康的确切影响仍在评估中。此外，人们尚未对其可能对心血管修复和再生细胞（如 EPC 或多能干细胞）产生的负面影响进行描述。有鉴于此，我们批判性地回顾了关于 MRPs 对心血管修复和再生分子及细胞机制影响的现有数据。
