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早期产后出血的保守手术治疗:泰国南部一家三级医疗中心的12年经验

Conservative Surgical Management of Early Postpartum Hemorrhage: A 12-Year Experience in a Tertiary Care Center in the South of Thailand.

作者信息

Klangsin Satit, Booncharoen Pichaya, Suwanrath Chitkasaem

机构信息

Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Songkhla, 90110 Thailand.

出版信息

J Obstet Gynaecol India. 2022 Aug;72(Suppl 1):180-185. doi: 10.1007/s13224-022-01628-9. Epub 2022 Feb 23.

Abstract

BACKGROUND/PURPOSE OF THE STUDY: To evaluate the success rate and predictive factors of success in conservative surgical management of early postpartum hemorrhage (PPH).

METHODS

A retrospective study was conducted at a tertiary care hospital in the south of Thailand, from January 2006 to December 2017. PPH with conservative surgical management including Bakri balloon tamponade, B-Lynch uterine compression sutures, arterial embolization, vessel ligations, and combined surgical procedures was reviewed. The procedures were considered successful if bleeding could be controlled without subsequent hysterectomy. Multivariate logistic regression analysis was used to identify predictive factors for success of conservative surgical treatment.

RESULTS

Among 39,327 deliveries, 1461 (3.7%) patients had early PPH, and 92 cases received conservative surgical management. Most patients (92.4%) underwent cesarean section. Median (IQR) blood loss before conservative surgery was 1800 (1100, 2575) mL, and median (IQR) time from early PPH to conservative surgical management was 41 (25.5, 60.0) minutes. The overall success rate of conservative surgical management was 80.4%, meanwhile the postoperative complication rate was 27.2%. The predictive factors significantly associated with success were maternal age < 35 years (odds ratio [OR] 4.53, 95% confidence interval [CI] 1.27-16.23;  = 0.02), blood loss before conservative surgery < 1800 mL (OR 5.82, 95% CI 1.45-23.33;  = 0.01), and time to start conservative surgery ≤ 40 min (OR 4.76, 95% CI 1.13-20.12;  = 0.03).

CONCLUSION

The overall success rate of conservative surgical procedures was high. Maternal age < 35 years, blood loss before conservative management < 1800 mL, and time to conservative surgery ≤ 40 min were predictive factors of success.

摘要

研究背景/目的:评估早期产后出血(PPH)保守手术治疗的成功率及成功的预测因素。

方法

于2006年1月至2017年12月在泰国南部一家三级护理医院进行一项回顾性研究。对采用包括Bakri球囊填塞、B-Lynch子宫压迫缝合、动脉栓塞、血管结扎及联合手术等保守手术治疗的PPH病例进行回顾。若出血能够得到控制且无需后续子宫切除,则认为手术成功。采用多因素logistic回归分析确定保守手术治疗成功的预测因素。

结果

在39327例分娩中,1461例(3.7%)患者发生早期PPH,92例接受了保守手术治疗。大多数患者(92.4%)接受了剖宫产。保守手术前的中位(四分位间距)失血量为1800(1100,2575)mL,从早期PPH至保守手术治疗的中位(四分位间距)时间为41(25.5,60.0)分钟。保守手术治疗的总体成功率为80.4%,同时术后并发症发生率为27.2%。与成功显著相关的预测因素为产妇年龄<35岁(比值比[OR]4.53,95%置信区间[CI]1.27 - 16.23;P = 0.02)、保守手术前失血量<1800 mL(OR 5.82,95% CI 1.45 - 23.33;P = 0.01)以及开始保守手术的时间≤40分钟(OR 4.76,95% CI 1.13 - 20.12;P = 0.03)。

结论

保守手术治疗的总体成功率较高。产妇年龄<35岁、保守治疗前失血量<1800 mL以及保守手术时间≤40分钟是成功的预测因素。

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Postpartum haemorrhage: prevention and treatment.产后出血:预防与治疗。
Expert Rev Hematol. 2016 Nov;9(11):1043-1061. doi: 10.1080/17474086.2016.1245135. Epub 2016 Oct 20.
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Global causes of maternal death: a WHO systematic analysis.全球孕产妇死亡原因:世卫组织系统分析。
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