Rogier Eric, Nace Doug, Dimbu Pedro R, Wakeman Brian, Beeson James G, Drakeley Chris, Tetteh Kevin, Plucinski Mateusz
Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, United States.
National Malaria Control Program, Luanda, Angola.
Front Med (Lausanne). 2022 Jul 19;9:869028. doi: 10.3389/fmed.2022.869028. eCollection 2022.
Immunoglobulin (Ig) production during and after infection with parasites is one of the greatest adaptive immune defenses the human host has against this parasite. Infection with has been shown to induce different B cell maturation responses dependent upon the age of the patient, number of previous exposures, and severity of the disease. Described here are dynamics of Ig responses to a panel of 32 antigens by patients followed for 42 days and classified individuals as showing characteristics of an apparent first infection (naïve) or a repeat exposure (non-naïve). Six parameters were modeled to characterize the dynamics of IgM, IgG, IgG, and IgA for these two exposure groups with differences assessed among Ig isotypes/subclasses and unique antigens. Naïve patients had significantly longer periods of time to reach peak Ig titer (range 4-7 days longer) and lower maximum Ig titers when compared with non-naïve patients. Modeled time to seronegativity was significantly higher in non-naïve patients for IgM and IgA, but not for the two IgG subclasses. IgG responses to Rh2030, HSP40, and PfAMA1 were at the highest levels for non-naïve participants and may be used to predict previous or nascent exposure by themselves. The analyses presented here demonstrate the differences in the development of the Ig response to if the infection represents a boosting response or a primary exposure. Consistency in Ig isotype/subclasses estimates and specific data for antigens can better guide interpretation of seroepidemiological data among symptomatic persons.
感染寄生虫期间及之后免疫球蛋白（Ig）的产生是人类宿主对抗该寄生虫的最强大适应性免疫防御之一。已证明感染[寄生虫名称未给出]会根据患者年龄、既往接触次数和疾病严重程度诱导不同的B细胞成熟反应。本文描述了患者对一组32种[寄生虫名称未给出]抗原的Ig反应动态，随访42天，并将个体分类为表现出初次感染（天真型）或再次接触（非天真型）的特征。对六个参数进行建模，以表征这两个接触组中IgM、IgG、IgG和IgA的动态，评估Ig同种型/亚类和独特抗原之间的差异。与非天真型患者相比，天真型患者达到Ig滴度峰值的时间明显更长（范围长4 - 7天），且最大Ig滴度更低。非天真型患者中，IgM和IgA的血清阴性建模时间显著更高，但两个IgG亚类则不然。非天真型参与者对Rh2030、HSP40和PfAMA1的IgG反应处于最高水平，其自身可用于预测既往或新发生的接触。本文的分析表明，如果感染代表增强反应或初次接触，对[寄生虫名称未给出]的Ig反应发展存在差异。Ig同种型/亚类估计的一致性以及[寄生虫名称未给出]抗原的具体数据可以更好地指导对有症状人群血清流行病学数据的解释。
