Department of Hematology and Oncology, King Hussein Medical City, Amman, Jordan.
Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa, Jordan.
J Med Life. 2022 Jun;15(6):867-870. doi: 10.25122/jml-2021-0283.
Snakebites have been reported to induce hematological complications. Thrombocytopenia usually occurs secondary to disseminated intravascular coagulation (DIC) and coagulopathy induced by the snake bite. However, thrombocytopenia can develop after the snake bite, even in the absence of significant coagulopathy. We reported the case of a 36-year-old Jordanian male patient who was bitten by Arabian Macrovipera Lebetina Obtusa (Levantine viper), which developed venom-induced severe thrombocytopenia without coagulopathy. A progressive drop in platelet count was observed during his admission. His condition improved after anti-venom therapy, and he was discharged after 4 weeks of treatment for a full recovery. This case supports that snake venom can produce severe thrombocytopenia without significant coagulopathy, which can be treated successfully with anti-venom and the best supportive care.
蛇咬伤可引起血液学并发症。血小板减少症通常继发于蛇咬伤引起的弥散性血管内凝血（DIC）和凝血障碍。然而，即使没有明显的凝血障碍，蛇咬伤后也可能发生血小板减少症。我们报告了一例 36 岁的约旦男性患者，他被阿拉伯 Macrovipera Lebetina Obtusa（Levantine 蝰蛇）咬伤，发生了毒液诱导的严重血小板减少症，而无凝血障碍。在住院期间观察到血小板计数逐渐下降。在抗蛇毒治疗后病情改善，经过 4 周的治疗后完全康复出院。本例支持蛇毒可引起严重无明显凝血障碍的血小板减少症，抗蛇毒和最佳支持治疗可成功治疗。
