Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, National and Kapodistrian University of Athens, Athens, Greece.
Department of Obstetrics and Gynecology, Tzaneio Hospital, Athens, Greece.
J Med Life. 2022 Jun;15(6):742-746. doi: 10.25122/jml-2021-0329.
For the last decades, endometriosis has been a major gynecological problem and a significant cause of infertility for women worldwide. It is estimated that the disease affects about 10-15% of all women of reproductive age and 70% of women suffering from chronic pelvic pain. At the same time, the incidence is about 40-60% in women with dysmenorrhea and 20-30% in women with subfertility. Despite the high percentage of affected women, endometriosis is still characterized by insufficient knowledge of the pathogenic processes, leading to the development and continuity of the disease. For this reason, there is a significant need for insight and understanding of the pathogenesis of endometriosis. This systematic review aims to present the latest data on the use of rats in endometriosis research and to explore how fertility is affected in rats with endometriosis. The methodology included a review of the available publications retrieved by a search in various scientific databases, such as PubMed, Scopus, Medline, and Google Scholar. The initial search generated 30 titles, with 10 articles fulfilling the inclusion criteria. In conclusion, several surgical techniques have been proposed to induce endometriosis, mainly using rats as the appropriate animal model. Studies in rats showed that endometriosis causes infertility and that pregnancy rates are lower for rats with endometriosis than those without endometriosis. In addition, rats with endometriosis have significant abnormalities in the structure of their oocytes as well as in the development of their embryos (genetic abnormalities).
在过去的几十年中，子宫内膜异位症一直是一个主要的妇科问题，也是全球女性不孕的一个重要原因。据估计，这种疾病影响了大约 10-15%的所有育龄妇女，以及 70%的慢性盆腔疼痛妇女。同时，在痛经妇女中发病率约为 40-60%，在不孕妇女中发病率约为 20-30%。尽管受影响的女性比例很高，但子宫内膜异位症的发病机制仍缺乏足够的认识，导致疾病的发展和持续。因此，需要深入了解子宫内膜异位症的发病机制。本系统评价旨在介绍目前关于在子宫内膜异位症研究中使用大鼠的最新数据，并探讨子宫内膜异位症对大鼠生育能力的影响。该方法包括对从各种科学数据库（如 PubMed、Scopus、Medline 和 Google Scholar）中检索到的现有出版物进行综述。最初的搜索生成了 30 个标题，其中 10 篇文章符合纳入标准。总之，已经提出了几种诱导子宫内膜异位症的手术技术，主要使用大鼠作为合适的动物模型。大鼠研究表明，子宫内膜异位症会导致不孕，并且患有子宫内膜异位症的大鼠的妊娠率低于没有子宫内膜异位症的大鼠。此外，患有子宫内膜异位症的大鼠的卵子结构和胚胎发育（遗传异常）存在显著异常。
