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The anti-Trop-2 antibody-drug conjugate Sacituzumab Govitecan-effectiveness, pitfalls and promises.

作者信息

Guerra Emanuela, Alberti Saverio

机构信息

Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST), University "G. D'Annunzio", Chieti, Italy.

Department of Medical, Oral and Biotechnological Sciences, University "G. D'Annunzio", Chieti, Italy.

出版信息

Ann Transl Med. 2022 May;10(9):501. doi: 10.21037/atm-22-621.

DOI:10.21037/atm-22-621
PMID:35928735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9347060/
Abstract
摘要

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The anti-Trop-2 antibody-drug conjugate Sacituzumab Govitecan-effectiveness, pitfalls and promises.抗 Trop-2 抗体药物偶联物戈沙妥珠单抗——疗效、陷阱与前景
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Datopotamab Deruxtecan in Advanced or Metastatic HR+/HER2- and Triple-Negative Breast Cancer: Results From the Phase I TROPION-PanTumor01 Study.在晚期或转移性 HR+/HER2-和三阴性乳腺癌中应用德曲妥珠单抗偶联物：TROPION-PanTumor01 研究的 I 期结果。
J Clin Oncol. 2024 Jul 1;42(19):2281-2294. doi: 10.1200/JCO.23.01909. Epub 2024 Apr 23.
2
An Insight into FDA Approved Antibody-Drug Conjugates for Cancer Therapy.深入了解 FDA 批准用于癌症治疗的抗体药物偶联物。
Molecules. 2021 Sep 27;26(19):5847. doi: 10.3390/molecules26195847.
3
Does sacituzumab-govitecan act as a conventional antibody drug conjugate (ADC), a prodrug of SN-38 or both?赛托珠单抗-戈维汀是作为传统抗体药物偶联物（ADC）、SN-38的前药，还是两者兼具？
Ann Transl Med. 2021 Jul;9(14):1113. doi: 10.21037/atm-21-1103.
4
Trop-2 induces ADAM10-mediated cleavage of E-cadherin and drives EMT-less metastasis in colon cancer.Trop-2 诱导 ADAM10 介导的 E-钙黏蛋白裂解，并驱动结肠癌 EMT 缺失转移。
Neoplasia. 2021 Sep;23(9):898-911. doi: 10.1016/j.neo.2021.07.002. Epub 2021 Jul 25.
5
Biomarker analyses in the phase III ASCENT study of sacituzumab govitecan versus chemotherapy in patients with metastatic triple-negative breast cancer.在转移性三阴性乳腺癌患者中 sacituzumab govitecan 与化疗对比的 III 期 ASCENT 研究中的生物标志物分析。
Ann Oncol. 2021 Sep;32(9):1148-1156. doi: 10.1016/j.annonc.2021.06.002. Epub 2021 Jun 8.
6
TROPHY-U-01: A Phase II Open-Label Study of Sacituzumab Govitecan in Patients With Metastatic Urothelial Carcinoma Progressing After Platinum-Based Chemotherapy and Checkpoint Inhibitors.TROPHY-U-01 研究：在铂类化疗和检查点抑制剂治疗后进展的转移性尿路上皮癌患者中 sacituzumab govitecan 的 II 期开放标签研究。
J Clin Oncol. 2021 Aug 1;39(22):2474-2485. doi: 10.1200/JCO.20.03489. Epub 2021 Apr 30.
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Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer.Sacituzumab Govitecan 治疗转移性三阴性乳腺癌。
N Engl J Med. 2021 Apr 22;384(16):1529-1541. doi: 10.1056/NEJMoa2028485.
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Trop-2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis.ADAM10 对 Trop-2 的裂解是促进肿瘤生长和转移的激活开关。
Neoplasia. 2021 Apr;23(4):415-428. doi: 10.1016/j.neo.2021.03.006. Epub 2021 Apr 8.
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Sacituzumab govitecan, a novel, third-generation, antibody-drug conjugate (ADC) for cancer therapy.注射用戈沙妥珠单抗，一种新型第三代抗体药物偶联物（ADC），用于癌症治疗。
Expert Opin Biol Ther. 2020 Aug;20(8):871-885. doi: 10.1080/14712598.2020.1757067. Epub 2020 May 12.
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Stable Isotope Dilution LC-HRMS Assay To Determine Free SN-38, Total SN-38, and SN-38G in a Tumor Xenograft Model after Intravenous Administration of Antibody-Drug Conjugate (Sacituzumab Govitecan).静脉注射抗体药物偶联物（Sacituzumab Govitecan）后肿瘤异种移植模型中游离 SN-38、总 SN-38 和 SN-38G 的稳定同位素稀释 LC-HRMS 测定法
Anal Chem. 2020 Jan 7;92(1):1260-1267. doi: 10.1021/acs.analchem.9b04419. Epub 2019 Dec 9.