Interactions of Colorectal Cancer, Dietary Fats, and Polymorphisms of Arachidonate Lipoxygenase and Cyclooxygenase Genes: A Literature Review.

OBJECTIVE

Genetics and dietary factors play important roles in the development of colorectal cancer (CRC). However, the underlying mechanisms of the interactions between CRC, gene polymorphisms, and dietary fat are unclear. This review study investigated the effects of polymorphisms of arachidonate lipoxygenase () and cyclooxygenase () genes in the association between CRC and dietary fat.

METHODS

All the related papers published from 2000 to 2022 were collected from different databases such as PubMed, Science Direct, Scopus, and Cochran using related keywords such as colorectal cancer, , , polymorphism, and dietary fat. Non-English and unrelated documents were excluded.

RESULTS

Some single-nucleotide polymorphisms () in the and genes, such as rs2228065, rs6413416, and rs4986832 in the gene, and rs689465 in the gene may play significant roles in the association between the risk of CRC and dietary fats. SNPs of ALOX and COX genes may influence the effects of dietary fatty acids on the risk of CRC.

CONCLUSION

Some polymorphisms of the and genes may have important roles in the effects of dietary fat on the risk of CRC. If future studies confirm these results, dietary recommendations for preventing colorectal cancer may be personalized based on the genotype of the and genes.