Inflammation Program, Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa, USA.
J Leukoc Biol. 2022 Oct;112(4):587-589. doi: 10.1002/JLB.4CE0422-232R. Epub 2022 Aug 4.
The text extracted from the initial paragraph of a paper coauthored by Zanvil Cohn, one of the pioneers in the study of leukocyte biology, highlights two phenomena that stimulated investigations of innate immunity in the middle of the last century, namely phagocytosis and intracellular antimicrobial activity. Although many features of phagocytosis have been characterized since that time, fundamental aspects of the antimicrobial action of neutrophils remain unknown. The report by Ashby et al. provides a refined and nuanced look at the interface between an ingested microbe, Staphylococcus aureus, and HOCl generated by the myeloperoxidase (MPO)-H O -chloride system in neutrophil phagosomes and represents a holistic approach to the analysis of bactericidal mechanisms that recognizes contributions from both phagocyte and its ingested prey.
本文节选自白细胞生物学研究先驱 Zanvil Cohn 等人合著的一篇论文的开篇段落，其中强调了两个现象，正是这两个现象在上世纪中期刺激了人们对固有免疫的研究，即吞噬作用和细胞内抗菌活性。自那时以来，人们已经对吞噬作用的许多特征进行了描述，但中性粒细胞的抗菌作用的基本方面仍不清楚。Ashby 等人的报告对被吞噬微生物金黄色葡萄球菌与中性粒细胞吞噬体中髓过氧化物酶 (MPO)-H 2 O 2 - 氯离子系统产生的次氯酸之间的相互作用进行了细致入微的观察，代表了一种全面分析杀菌机制的方法，该方法既认识到吞噬细胞本身的作用，也认识到被吞噬猎物的作用。
