压缩弹性成像和剪切波超声弹性成像测量足月和早产儿脑弹性的前瞻性研究。

Compression Elastography and Shear Wave Ultrasound Elastography for Measurement of Brain Elasticity in Full-Term and Premature Neonates: A Prospective Study.

机构信息

Department of Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangdong, China.

Department of Ultrasound Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangdong, China.

出版信息

J Ultrasound Med. 2023 Jan;42(1):221-231. doi: 10.1002/jum.16075. Epub 2022 Aug 4.

DOI:10.1002/jum.16075

PMID:35929079

Abstract

OBJECTIVES

To investigate the brain tissue elasticity in normal term and premature neonates using compression elastography and shear wave elastography.

METHODS

This prospective observational study enrolled term and premature neonates admitted to the Third Affiliated Hospital of Guangzhou Medical University between July 2019 and December 2020.

RESULTS

A total of 106 neonates, including 65 premature neonates and 41 term neonates, were enrolled. The elastic modulus of the frontal white matter in males was significantly lower than in females (11.67 ± 0.98 versus 12.25 ± 1.31, P = .030), but the shear wave velocity of the thalamus in males was significantly lower than in females (1.18 ± 0.13 versus 1.82 ± 0.10, P < .001). There was no significant correlation between real-time body weight and brain tissue elasticity including elastic modulus and shear wave velocity. But, the shear wave velocity of parietal white matter (r = 0.319, P = .014) and thalamus (r = -0.268, P = .040) and the elastic modulus of parietal white matter (r = 0.356, P = .006) were correlated with corrected gestational age.

CONCLUSIONS

Clinicians may consider using elastography to determine brain tissue elasticity in term and preterm neonates.

摘要

目的

使用压缩弹性成像和剪切波弹性成像技术研究正常足月和早产儿的脑组织弹性。

方法

本前瞻性观察性研究纳入了 2019 年 7 月至 2020 年 12 月期间广州医科大学附属第三医院收治的足月和早产儿。

结果

共纳入 106 例新生儿，其中早产儿 65 例，足月儿 41 例。男性额白质的弹性模量显著低于女性（11.67±0.98 比 12.25±1.31，P=0.030），而男性丘脑的剪切波速度显著低于女性（1.18±0.13 比 1.82±0.10，P<0.001）。实时体重与脑组织弹性（包括弹性模量和剪切波速度）之间无显著相关性。然而，顶叶白质（r=0.319，P=0.014）和丘脑（r=-0.268，P=0.040）的剪切波速度以及顶叶白质的弹性模量（r=0.356，P=0.006）与校正胎龄呈正相关。