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人类肝脏的长时间（超过 12 天）常温持续灌流。

Long-term normothermic perfusion of human livers for longer than 12 days.

机构信息

Australian National Liver Transplantation Unit, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

Centre for Organ Assessment Repair and Optimisation, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

出版信息

Artif Organs. 2022 Dec;46(12):2504-2510. doi: 10.1111/aor.14372. Epub 2022 Aug 5.

DOI:10.1111/aor.14372
PMID:35929443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9805080/
Abstract

In this case report, we preserved human livers for up to 13 days under normothermic conditions using a modified commercial perfusion system. Two whole livers were split into two left lateral segment grafts and two extended right grafts without interruption to blood flow and then perfused on separate machines. Not only does this provide the basis for a meaningful study of liver function in the long term, but this could also facilitate the development of a model of ex situ liver regeneration.

摘要

在本病例报告中，我们使用改良的商业化灌注系统，在常温条件下保存肝脏长达 13 天。两个完整的肝脏被分割成两个左外侧叶移植物和两个扩展的右移植物，血流没有中断，然后在单独的机器上进行灌注。这不仅为长期肝功能研究提供了基础，还可能促进离体肝脏再生模型的发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/9805080/25efe4f7fe79/AOR-46-2504-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/9805080/46854350ae2f/AOR-46-2504-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/9805080/09a574061b9c/AOR-46-2504-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/9805080/32b4c212f4da/AOR-46-2504-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/9805080/25efe4f7fe79/AOR-46-2504-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/9805080/46854350ae2f/AOR-46-2504-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/9805080/09a574061b9c/AOR-46-2504-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/9805080/32b4c212f4da/AOR-46-2504-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4c/9805080/25efe4f7fe79/AOR-46-2504-g001.jpg

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