Bychkov V G, Molokova O A, Zuevskiĭ V P
Arkh Patol. 1987;49(3):44-8.
Granulomatous liver inflammation was studied in Syrian hamsters in opisthorchiasis alone and in combination with different factors, such as carcinogens, anthelmintics, immunosuppressants and pregnancy. Parasitic ova and metabolites, as well as hepatic cell necrosis are shown to be the initiating factors of granulomatous inflammation. Granulomas originate in ductal walls, hepatic stroma and parenchyma. Four granuloma types are distinguished, i.e. macrophagal, giant-cell, necrotizing and cicatricial one. The biggest granuloma area was observed in superinvasive form of helminthiasis, when infection was combined with a carcinogen (DMNA), and in pregnant female hamsters treated with droncite. It is suggested that opisthorchiasis is a granulomatous disease.
在叙利亚仓鼠中，对单独感染后睾吸虫病以及感染后睾吸虫病并结合不同因素（如致癌物、驱虫药、免疫抑制剂和妊娠）时的肉芽肿性肝脏炎症进行了研究。研究表明，寄生虫卵和代谢产物以及肝细胞坏死是肉芽肿性炎症的起始因素。肉芽肿起源于胆管壁、肝间质和实质。区分出四种肉芽肿类型，即巨噬细胞型、巨细胞型、坏死型和瘢痕型。在蠕虫病的超侵袭形式（即感染与致癌物（DMNA）联合）以及用氯硝柳胺治疗的怀孕雌性仓鼠中，观察到最大的肉芽肿面积。提示后睾吸虫病是一种肉芽肿性疾病。
