[Morphofunctional correlates of the nephrotoxic action of cis-platin].

A single injection of 5 mg/kg cisplatin causes (in 2 days) focal changes in rat renal parenchyma. These changes correlate well with the decrease in glomerular filtration rate, increase in blood urea concentration, decrease in water load excretion. Cellular dystrophy was found in the convoluted and straight proximal renal tubules, in line with a marked thickening of basal membrane in damaged cells, that appears to account for the impairment of paraaminohippurate secretion, the increase of kidney mass and its swelling. On day 5 after injection the renal parenchyma exhibited signs of reparation, while renal function was abnormal.