Department of Pharmacy, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States of America.
Department of Pharmacy, University of New Mexico Hospital, Albuquerque, NM 87106, United States of America.
Am J Emerg Med. 2022 Oct;60:88-95. doi: 10.1016/j.ajem.2022.07.039. Epub 2022 Jul 25.
This article highlights the most relevant emergency medicine (EM) pharmacotherapy publications indexed in 2021. A modified Delphi approach was utilized for selected journals to identify the most impactful EM pharmacotherapy studies via the GRADE system. After review of journal table of contents GRADE 1A and 1B articles were reviewed by authors. Twenty articles, 2 guidelines, 2 position papers, and 2 meta-analysis were selected for full summary. Articles included in this review highlight acute agitation management, acute appendicitis treatment, sexually transmitted infection updates, optimizing sepsis management and treatment, updates for the ideal thrombolytic agent in acute ischemic stroke and endovascular therapy candidates, indications for tranexamic acid, calicium for out of hospital cardiac arrest, optimial inotrope for cardiogenic shock, awareness during rapid sequence intubation paralysis, comparison of propofol or dexmedetomidine for sedation, treatment of cannabis hyperemsis syndrome, and prophylactic use of diphenhydramine to reduce neuroleptic side effects. Selected articles are summarized to include design, results, limitations, conclusions and impact.
本文重点介绍了 2021 年索引的最相关的急诊医学（EM）药物治疗学出版物。通过 GRADE 系统，采用改良 Delphi 方法对选定的期刊进行了最具影响力的 EM 药物治疗研究的选择。在审查期刊目录后，作者对 GRADE 1A 和 1B 文章进行了审查。选择了 20 篇文章、2 项指南、2 份立场文件和 2 项荟萃分析进行全面总结。本综述中包含的文章重点介绍了急性激越管理、急性阑尾炎治疗、性传播感染更新、优化脓毒症管理和治疗、急性缺血性脑卒中理想溶栓剂和血管内治疗候选者更新、氨甲环酸的适应证、院外心脏骤停的钙、心源性休克的最佳正性肌力药、快速序贯插管麻痹时的意识、丙泊酚或右美托咪定镇静的比较、大麻过度兴奋综合征的治疗以及预防使用苯海拉明以减少神经阻滞剂的副作用。总结了选定的文章，包括设计、结果、局限性、结论和影响。
