侵袭性神经胶质瘤细胞：顺势而为的恶性先驱
Invasive glioma cells: The malignant pioneers that follow the current.
机构信息
Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA; Howard Hughes Medical Institute, Stanford, CA, USA.
出版信息
Cell. 2022 Aug 4;185(16):2846-2848. doi: 10.1016/j.cell.2022.06.033.
Glioblastoma is a lethal, diffusely invasive brain cancer that is robustly regulated by the activity of the brain itself, in part through neuron-to-glioma synaptic communication. Venkataramani et al. have conceptually advanced understanding of glioblastoma interactions with neural circuits, demonstrating that conduction of electrochemical signals via neuron-to-glioma synapses drives glioma invasion.
胶质母细胞瘤是一种致命的、弥漫性浸润性脑癌，其本身的活动在一定程度上受到大脑的强烈调节，部分是通过神经元-胶质瘤突触通讯。Venkataramani 等人对胶质母细胞瘤与神经回路的相互作用有了概念上的深入理解，证明了通过神经元-胶质瘤突触传递电化学信号会驱动胶质瘤的侵袭。
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