压力与 CITI。
Stress and the CITI.
机构信息
Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Urology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX 75390, USA.
出版信息
Mol Cell. 2022 Aug 4;82(15):2730-2731. doi: 10.1016/j.molcel.2022.07.002.
Transcription-coupled cellular stress is associated with several physiological and pathological features, including membraneless biomolecular condensates. In the study by Yasuhara et al., the authors have described specific nuclear condensates in multiple cell types upon inhibition of RNA polymerase II transcription, discovered their main constituent proteins, and elucidated their functions.
转录偶联的细胞应激与多种生理和病理特征有关，包括无膜生物分子凝聚物。在 Yasuhara 等人的研究中，作者描述了 RNA 聚合酶 II 转录抑制后多种细胞类型中的特定核凝聚物，发现了它们的主要组成蛋白，并阐明了它们的功能。
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