Kainulainen H, Komulainen J, Takala T, Vihko V
Basic Res Cardiol. 1987 Jan-Feb;82(1):9-17. doi: 10.1007/BF01907048.
The effect of 10 weeks of running training and termination of training on the regional distribution of cardiac glucose uptake and protein synthesis were studied in isolated perfused hearts in male rats. The left ventricular glucose uptake in hearts from sedentary rats was 1.87 +/- 0.14 mumol/min per g protein (mean +/- SE), being about 30% higher in the subendocardial than in the subepicardial layer (p less than 0.05). The gradient of left ventricular glucose uptake was similar to the controls in the rats retired from training, but was absent in the trained animals. The altered transmural glucose uptake probably reflects differences in the adaptive response of various myocardial muscle layers to a long-term intermittent increase in cardiac work load. Phenylalanine incorporation was evenly distributed through the left ventricle in all the groups, but was lowered in the left and right ventricles of the trained rats. Phenylalanine incorporation returned to the control level 5 weeks after the cessation of training.
在雄性大鼠的离体灌注心脏中，研究了为期10周的跑步训练及训练终止对心脏葡萄糖摄取和蛋白质合成区域分布的影响。久坐不动的大鼠心脏左心室葡萄糖摄取量为每克蛋白质1.87±0.14微摩尔/分钟（平均值±标准误），心内膜下层比心外膜下层高约30%（p<0.05）。从训练中退出的大鼠左心室葡萄糖摄取梯度与对照组相似，但训练过的动物中不存在这种梯度。跨壁葡萄糖摄取的改变可能反映了不同心肌层对心脏工作负荷长期间歇性增加的适应性反应差异。所有组中苯丙氨酸掺入在左心室内均匀分布，但训练大鼠的左心室和右心室中苯丙氨酸掺入量降低。训练停止5周后，苯丙氨酸掺入量恢复到对照水平。
