Diabetes, Endocrinology and Obesity Medicine, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK.
Undergraduate Medical Education, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK.
Clin Obes. 2022 Oct;12(5):e12546. doi: 10.1111/cob.12546. Epub 2022 Aug 6.
Bardet-Biedl syndrome (BBS) is a rare genetic condition, characterized by ciliary protein dysfunction, leading to multi-organ damage. People with BBS can develop early-onset severe obesity and associated problems including the metabolic syndrome, type 2 diabetes and coronary heart disease. Weight management can be challenging with the lack of effective medical therapies so far. We report a patient with BBS who underwent successful weight reduction through the use of glucagon-like peptide-1 receptor agonists.
Bardet-Biedl 综合征（BBS）是一种罕见的遗传性疾病，其特征是纤毛蛋白功能障碍，导致多器官损伤。BBS 患者可能会出现早发性严重肥胖症以及相关问题，包括代谢综合征、2 型糖尿病和冠心病。到目前为止，由于缺乏有效的医学治疗方法，体重管理颇具挑战。我们报告了一例 BBS 患者，他通过使用胰高血糖素样肽-1 受体激动剂成功减肥。
