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术后类固醇治疗组织学证实的干燥性闭塞性龟头炎的男孩可减少后续尿道扩张的需求。

Post-operative steroids in boys with histologically proven balanitis xerotica obliterans reduce the need for subsequent meatal dilatation.

机构信息

Department of Paediatric Surgery, St George's Hospital, London, United Kingdom.

出版信息

J Paediatr Child Health. 2022 Nov;58(11):2034-2038. doi: 10.1111/jpc.16145. Epub 2022 Aug 6.

Abstract

AIM

Post-circumcision topical steroids may reduce the number of patients with balanitis xerotica obliterans (BXO) who require subsequent meatal dilatation. However, their use has only been investigated in the presence of an abnormal urethral meatus. The aim of this study is to determine if post-operative topical steroids reduce the need for subsequent meatal dilatation in patients with histologically proven BXO independent of the appearance of the urethral meatus. To determine if post-operative topical steroids reduce the need for subsequent meatal procedures in patients with histologically proven BXO. To determine if the appearance of the meatus at circumcision affects the need for subsequent meatal procedure.

METHODS

We performed a retrospective review of all paediatric patients with histologically confirmed BXO post circumcision. We excluded all those with 'chronic inflammation' or 'early BXO'. Patients were divided into groups based on whether post-operative topical steroids were prescribed. The appearance of the urethral meatus at circumcision was recorded. Primary outcome was progression to subsequent meatal dilatation. Statistical significance was calculated using Fisher's exact test. A P value < 0.05 was considered significant.

RESULTS

One hundred and seventeen patients with histologically confirmed BXO were identified between October 2012 and December 2017. Fifty-nine patients were prescribed post-operative topical steroids (50%). Nine patients required subsequent meatal dilatation procedure (8%) and only one of these had been prescribed post-operative topical steroids (P = 0.0165). Abnormal meatus was noted in 24 (21%) patients. Three patients in this group required subsequent meatal dilatation compared with 6 in the group with a normal meatal appearance (P = 0.385).

CONCLUSIONS

Post-operative topical steroids can reduce the need for subsequent meatal dilatation in boys with BXO. The appearance of the urethral meatus at circumcision does not predict the need for subsequent meatal dilatation.

摘要

目的

包皮环切术后局部使用类固醇可能会减少需要后续尿道扩张术的干燥性龟头炎(BXO)患者数量。然而,其仅在存在异常尿道外口的情况下进行了研究。本研究旨在确定术后局部使用类固醇是否可以减少组织学证实的 BXO 患者后续尿道扩张术的需求,而与尿道外口的外观无关。确定术后局部使用类固醇是否可以减少组织学证实的 BXO 患者后续尿道扩张术的需求。确定包皮环切术时尿道外口的外观是否影响后续尿道扩张术的需求。

方法

我们对所有组织学证实的包皮环切术后 BXO 患儿进行了回顾性研究。我们排除了所有具有“慢性炎症”或“早期 BXO”的患者。根据是否开具术后局部类固醇药物,将患者分为两组。记录包皮环切术时尿道外口的外观。主要结局是进展为后续尿道扩张术。使用 Fisher 精确检验计算统计学意义。P 值<0.05 被认为具有统计学意义。

结果

2012 年 10 月至 2017 年 12 月期间,共确定了 117 例组织学证实的 BXO 患儿。59 例患者开具了术后局部类固醇药物(50%)。9 例患者需要进行后续尿道扩张术(8%),其中仅 1 例患者开具了术后局部类固醇药物(P=0.0165)。24 例(21%)患者的尿道外口异常。在该组中,有 3 例患者需要进行后续尿道扩张术,而在尿道外口正常的组中,有 6 例患者需要进行后续尿道扩张术(P=0.385)。

结论

包皮环切术后局部使用类固醇可以减少 BXO 患儿后续尿道扩张术的需求。包皮环切术时尿道外口的外观并不能预测后续尿道扩张术的需求。

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