Ningxia Key Laboratory of Cerebrocranial Disease, Ningxia Medical University, Yinchuan, Ningxia, China.
Ningxia Key Laboratory of Cerebrocranial Disease, Ningxia Medical University, Yinchuan, Ningxia, China.
Biochem Biophys Res Commun. 2022 Oct 8;624:47-52. doi: 10.1016/j.bbrc.2022.07.078. Epub 2022 Jul 31.
Sleep deprivation is an important cause of cognitive impairment, and anterior insular subregions are core brain regions linked to cognitive function. However, the relationship between anterior insular subregions functional connectivity (FC) and the cognitive impairment that occurs following total sleep deprivation (TSD) remains unknown. As such, this study was designed to evaluate how such anterior insular subregions FC alterations are linked with impaired cognitive activity after TSD. This study recruited 20 healthy volunteers who underwent two rounds of resting-state functional magnetic resonance imaging (rs-fMRI), with one being conducted while in a state of rested wakefulness (RW) and the other being conducted following 24 h of TSD. These rs-fMRI data were then used to conduct seed-based FC analyses for the bilateral anterior insular subregions, including the dorsal anterior insula (dAI) and the ventral anterior insula (vAI). The Psychomotor Vigilance Test (PVT) was used to gauge cognitive performance, and associations between altered FC in these anterior insular subregions and PVT performance following TSD were measured using Pearson correlation analyses. Significant changes in the FC of these bilateral insular subregions were observed following 24 h of TSD relative to the RW state. Significantly enhanced FC was evident between the left dAI and right superior frontal gyrus (SFG), right dAI and bilateral SFG and right putamen, and right vAI and left medial SFG. Moreover, the observed enhancement of FC between the left vAI and right SFG functional connectivity was positively correlated with worse PVT performance. These data suggest that altered FC in the anterior insular subregions represents a prominent neuroimaging biomarker associated with cognitive impairment following TSD.
睡眠剥夺是认知障碍的一个重要原因，而前脑岛亚区是与认知功能相关的核心脑区。然而，总的睡眠剥夺（TSD）后前脑岛亚区功能连接（FC）与认知障碍之间的关系尚不清楚。因此，本研究旨在评估前脑岛亚区 FC 的改变与 TSD 后认知活动受损之间的关系。本研究招募了 20 名健康志愿者，他们接受了两轮静息态功能磁共振成像（rs-fMRI）检查，一轮在清醒静息状态（RW）下进行，另一轮在 24 小时 TSD 后进行。然后，使用这些 rs-fMRI 数据对双侧前脑岛亚区（包括背侧前脑岛（dAI）和腹侧前脑岛（vAI））进行基于种子的 FC 分析。使用精神运动警觉测试（PVT）来评估认知表现，并使用 Pearson 相关分析测量这些前脑岛亚区 FC 改变与 TSD 后 PVT 表现之间的相关性。与 RW 状态相比，TSD 后这些双侧脑岛亚区的 FC 发生了显著变化。左 dAI 与右额上回（SFG）、右 dAI 与双侧 SFG 和右壳核、右 vAI 与左内侧 SFG 之间的 FC 明显增强。此外，观察到的左 vAI 与右 SFG 功能连接之间的 FC 增强与 PVT 表现恶化呈正相关。这些数据表明，前脑岛亚区的 FC 改变代表了与 TSD 后认知障碍相关的突出神经影像学生物标志物。
