Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), Madrid, Spain; Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain; Universidad Autónoma de Madrid, Madrid, Spain.
Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), Madrid, Spain; Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
Pharmacol Res. 2022 Sep;183:106386. doi: 10.1016/j.phrs.2022.106386. Epub 2022 Aug 4.
Iron participates in myriad processes necessary to sustain life. During the past decades, great efforts have been made to understand iron regulation and function in health and disease. Indeed, iron is associated with both physiological (e.g., immune cell biology and function and hematopoiesis) and pathological (e.g., inflammatory and infectious diseases, ferroptosis and ferritinophagy) processes, yet few studies have addressed the potential functional link between iron, the aforementioned processes and extramedullary hematopoiesis, despite the obvious benefits that this could bring to clinical practice. Further investigation in this direction will shape the future development of individualized treatments for iron-linked diseases and chronic inflammatory disorders, including extramedullary hematopoiesis, metabolic syndrome, cardiovascular diseases and cancer.
铁参与维持生命所必需的众多过程。在过去的几十年中，人们做出了巨大的努力来理解铁在健康和疾病中的调节和功能。事实上，铁与生理过程（如免疫细胞生物学和功能以及造血）和病理过程（如炎症和传染病、铁死亡和铁蛋白自噬）都有关联，但很少有研究探讨铁、上述过程和骨髓外造血之间的潜在功能联系，尽管这显然会给临床实践带来益处。在这一方向上的进一步研究将塑造针对与铁相关的疾病和慢性炎症性疾病（包括骨髓外造血、代谢综合征、心血管疾病和癌症）的个体化治疗的未来发展。
