脂氧素A和脂氧素B对人粒细胞功能反应的影响。

The effects of lipoxin A and lipoxin B on functional responses of human granulocytes.

作者信息

Palmblad J, Gyllenhammar H, Ringertz B, Serhan C N, Samuelsson B, Nicolaou K C

出版信息

Biochem Biophys Res Commun. 1987 May 29;145(1):168-75. doi: 10.1016/0006-291x(87)91302-7.

Abstract

Lipoxin A and lipoxin B (LXA and LXB) are formed from arachidonic acid by leukocyte 5- and 15-lipoxygenases. We have assessed the effects of synthetic lipoxins on functional responses of human granulocytes. LXA stimulated migration at 1 nM. The effect was highly stereospecific, since e.g. 6S-LXA and LXB were less active than LXA. Neither synthetic LXA nor several of its stereoisomers provoked degranulation or aggregation. LXB and its isomers did not induce any of these functional responses. These results indicate that migratory granulocyte responses to LXA are highly stereospecific.

摘要

脂氧素A和脂氧素B（LXA和LXB）由花生四烯酸通过白细胞5-脂氧合酶和15-脂氧合酶生成。我们评估了合成脂氧素对人粒细胞功能反应的影响。LXA在1 nM时刺激细胞迁移。该效应具有高度立体特异性，例如6S-LXA和LXB的活性低于LXA。合成LXA及其几种立体异构体均未引发脱颗粒或聚集。LXB及其异构体未诱导任何这些功能反应。这些结果表明粒细胞对LXA的迁移反应具有高度立体特异性。