磷脂酰丝氨酸囊泡可提高大鼠脑突触体腺苷酸环化酶的活性。
Phosphatidylserine vesicles increase rat brain synaptosomal adenylate cyclase activity.
作者信息
Floreani M, Carpenedo F
出版信息
Biochem Biophys Res Commun. 1987 May 29;145(1):631-6. doi: 10.1016/0006-291x(87)91367-2.
PMID:3593357
Abstract
Phosphatidylserine vesicles incubated in hypotonic conditions with rat brain synaptosomes increased basal adenylate cyclase activity but did not modify the response of the enzyme to norepinephrine. Moreover, phosphatidylserine antagonized the stimulation of adenylate cyclase activity by NaF. We suggest that in present experimental conditions the effect of phosphatidylserine vesicles is at the level of the GS regulatory protein of adenylate cyclase.
摘要
在低渗条件下与大鼠脑突触体一起孵育的磷脂酰丝氨酸囊泡可增加基础腺苷酸环化酶活性，但不会改变该酶对去甲肾上腺素的反应。此外，磷脂酰丝氨酸可拮抗氟化钠对腺苷酸环化酶活性的刺激作用。我们认为，在目前的实验条件下，磷脂酰丝氨酸囊泡的作用是在腺苷酸环化酶的GS调节蛋白水平上。
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