EZH2 在风湿性疾病中的新兴作用：全面综述。
Emerging role of EZH2 in rheumatic diseases: A comprehensive review.
机构信息
Department of Evidence-Based Medicine, Southwest Medical University, Luzhou, China.
Department of Rheumatology and Immunology, Affiliated Hospital of Southwest Medical University, Luzhou, China.
出版信息
Int J Rheum Dis. 2022 Nov;25(11):1230-1238. doi: 10.1111/1756-185X.14416. Epub 2022 Aug 7.
Enhancer of zeste homolog 2 (EZH2) is a histone methylated enzyme. It trimethylates histone 3 lysine 27 (H3K27) to regulate epigenetic processes. Recently, studies showed excessive expression of EZH2 in rheumatic diseases, such as systemic lupus erythematosus, rheumatoid arthritis, osteoarthritis, and systemic sclerosis. Moreover, epigenetic modification of EZH2 regulates differentiation and proliferation of different immune cells. Therefore, in this review, we comprehensively discuss the role of EZH2 in rheumatic diseases. Collection of the evidence may provide a basis for further understanding the role of EZH2 and give potential for targeting these diseases.
增强子结合锌指蛋白 2（EZH2）是一种组蛋白甲基化酶。它通过三甲基化组蛋白 3 赖氨酸 27（H3K27）来调节表观遗传过程。最近的研究表明，EZH2 在风湿性疾病（如系统性红斑狼疮、类风湿关节炎、骨关节炎和系统性硬化症）中过度表达。此外，EZH2 的表观遗传修饰调节不同免疫细胞的分化和增殖。因此，在这篇综述中，我们全面讨论了 EZH2 在风湿性疾病中的作用。证据的收集可能为进一步了解 EZH2 的作用提供依据，并为靶向这些疾病提供潜在的可能性。
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