Department of Otolaryngology-Head and Neck Surgery, Kaiser Permanente Oakland Medical Center, CA, USA.
Department of Pathology, Kaiser Permanente Oakland Medical Center, CA, USA.
Perm J. 2022 Jun 29;26(2):149-152. doi: 10.7812/TPP/21.184. Epub 2022 Jun 15.
Infantile myofibroma is a unique fibrous tumor encountered in the head and neck. Although the majority of cases are solitary nodules that require only conservative management, awareness of the possibility of multicentric disease is important considering its substantial morbidity. A 3-month-old girl presenting with an enlarging 2.5-cm firm, mobile, nontender subcutaneous scalp mass was evaluated with magnetic resonance imaging and biopsy, revealing a diagnosis of infantile myofibroma. The literature was reviewed for supporting evidence of recommended management in a disease with no official treatment guidelines. Histological, genetic, and imaging characteristics are reviewed. Although biopsy is mandatory, conservative management can be employed for cases without multicentric involvement. Although there are no official guidelines for the evaluation of visceral involvement, skeletal radiograph and abdominal ultrasound are recommended. Infantile myofibroma is a distinct clinical entity with predilection for the head and neck. Its unique immunohistopathology and clinical course should be well understood and should be included in the differential diagnosis of infantile skin and subcutaneous masses.
婴儿肌纤维瘤是一种在头颈部发现的独特纤维性肿瘤。尽管大多数病例是仅需保守治疗的孤立性结节，但鉴于其发病率较高，了解多中心疾病的可能性很重要。一名 3 个月大的女婴因 2.5 厘米大的、坚实的、可移动的、无触痛的头皮皮下肿块而就诊，经磁共振成像和活检发现婴儿肌纤维瘤的诊断。对文献进行了回顾，以寻找在没有官方治疗指南的疾病中推荐管理的支持证据。回顾了组织学、遗传学和影像学特征。尽管活检是强制性的，但对于没有多中心受累的病例，可以采用保守治疗。虽然没有评估内脏受累的官方指南，但建议进行骨骼 X 线摄影和腹部超声检查。婴儿肌纤维瘤是一种具有头颈部偏好的独特临床实体。其独特的免疫组织病理学和临床病程应得到很好的理解，并应包括婴儿皮肤和皮下肿块的鉴别诊断。
